ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Wnt signal specifies the intrathalamic limit and its organizer properties by regulating Shh induction in the alar plate.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Spatiotemporal molecular dynamics of the developing human thalamus.Science (New York, N.Y.) · 2023Article
- Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis.Nature genetics · 2023Article
- A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone.Development (Cambridge, England) · 2023Article
- Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway.Marine drugs · 2022Article
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- Genesis of the Master Circadian Pacemaker in Mice.Frontiers in neuroscience · 2021Review
- Comprehensive bioinformatic analysis of Wnt1 and Wnt1-associated diseases.Intractable & rare diseases research · 2020Article
- Common and distinct transcriptional signatures of mammalian embryonic lethality.Nature communications · 2019Article
- Defining developmental diversification of diencephalon neurons through single cell gene expression profiling.Development (Cambridge, England) · 2019Article
- The Ciliopathy GeneThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer.Brain structure & function · 2019Article
- Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.Developmental biology · 2018Article
- Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma.Oncotarget · 2016Article
- An Evolutionarily Conserved Network Mediates Development of the zona limitans intrathalamica, a Sonic Hedgehog-Secreting Caudal Forebrain Signaling Center.Journal of developmental biology · 2016Review
- The origin and evolution of chordate nervous systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog.Frontiers in neuroanatomy · 2015Article
- Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer.Cell reports · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The structural complexity of the brain depends on precise molecular and cellular regulatory mechanisms orchestrated by regional morphogenetic organizers. The thalamic organizer is the zona limitans intrathalamica (ZLI), a transverse linear neuroepithelial domain in the alar plate of the diencephalon. Because of its production of Sonic hedgehog, ZLI acts as a morphogenetic signaling center. Shh is expressed early on in the prosencephalic basal plate and is then gradually activated dorsally within the ZLI. The anteroposterior positioning and the mechanism inducing Shh expression in ZLI cells are still partly unknown, being a subject of controversial interpretations. For instance, separate experimental results have suggested that juxtaposition of prechordal (rostral) and epichordal (caudal) neuroepithelium, anteroposterior encroachment of alar lunatic fringe (L-fng) expression, and/or basal Shh signaling is required for ZLI specification. Here we investigated a key role of Wnt signaling in the molecular regulation of ZLI positioning and Shh expression, using experimental embryology in ovo in the chick. Early Wnt expression in the ZLI regulates Gli3 and L-fng to generate a permissive territory in which Shh is progressively induced by planar signals of the basal plate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.