ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit.The Journal of comparative neurology · 2026Article
- Electrophysiological correlates of divergent projections in the avian superior olivary nucleus.Journal of neurophysiology · 2024Article
- Tonotopic differentiation of presynaptic neurotransmitter-releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice.The Journal of comparative neurology · 2022Article
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Dendritic synapse geometry optimizes binaural computation in a sound localization circuit.Science advances · 2021Article
- Excitatory-Inhibitory Synaptic Coupling in Avian Nucleus Magnocellularis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.Frontiers in neural circuits · 2020Review
- Neuronal sensitivity to the interaural time difference of the sound envelope in the mouse inferior colliculus.Hearing research · 2020Article
- Tonotopic Variation of the T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- Glycinergic inhibition tunes coincidence detection in the auditory brainstem.Nature communications · 2014Article
- Activity-dependent and activity-independent development of the axon initial segment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Slowly emerging glycinergic transmission enhances inhibition in the sound localization pathway of the avian auditory system.Journal of neurophysiology · 2014Article
- Resolution of interaural time differences in the avian sound localization circuit-a modeling study.Frontiers in computational neuroscience · 2014Article
- Glycinergic transmission modulates GABAergic inhibition in the avian auditory pathway.Frontiers in neural circuits · 2014Article
- Neuronal specializations for the processing of interaural difference cues in the chick.Frontiers in neural circuits · 2014Review
- Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.Frontiers in neural circuits · 2014Article
- The natural history of sound localization in mammals--a story of neuronal inhibition.Frontiers in neural circuits · 2014Article
- Detection of submillisecond spike timing differences based on delay-line anticoincidence detection.Journal of neurophysiology · 2013Article
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6 authors.
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Abstract
Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus is known to control the gain of coincidence detection, which allows the sensitivity of NL neurons to ITD tolerate strong-intensity sound. Here, we found a phasic inhibition in chicken brain slices that follows the ipsilateral NM inputs after a short time delay, sharpens coincidence detection, and may enhance ITD sensitivity in low-frequency NL neurons. GABA-positive small neurons are distributed in and near the NL. These neurons generate IPSCs in NL neurons when photoactivated by a caged glutamate compound, suggesting that these GABAergic neurons are interneurons that mediate phasic inhibition. These IPSCs have fast decay kinetics that is attributable to the α1-subunit of the GABAA receptor, the expression of which dominates in the low-frequency region of the NL. Model simulations demonstrate that phasic IPSCs narrow the time window of coincidence detection and increase the contrast of ITD-tuning during low-level, low-frequency excitatory input. Furthermore, cooperation of the phasic and sustained inhibitions effectively increases the contrast of ITD-tuning over a wide range of excitatory input levels. We propose that the complementary interaction between phasic and sustained inhibitions is the neural mechanism that regulates ITD sensitivity for low-frequency sound in the NL.
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