ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Latent modulation: a basis for non-disruptive promotion of two incompatible behaviors by a single network state.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Motor priming is associated with widespread recruitment into neural ensembles and more rapid ensemble transitions.iScience · 2026Article
- Variable task switching in the feeding network ofJournal of neurophysiology · 2023Article
- Persistent modulatory actions and task switching in the feeding network of Aplysia.Current opinion in neurobiology · 2023Review
- An Anticipatory Circuit Modification That Modifies Subsequent Task Switching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program inFrontiers in neural circuits · 2021Article
- Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis.The Biological bulletin · 2020Review
- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Network Degeneracy and the Dynamics of Task Switching in the Feeding Circuit inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Persistent effects of cyclic adenosine monophosphate are directly responsible for maintaining a neural network state.Scientific reports · 2019Article
- Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function.ACS chemical neuroscience · 2018Article
- Cellular Effects of Repetition Priming in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Identification and Characterization of Neuropeptides by Transcriptome and Proteome Analyses in a Bivalve MolluscFrontiers in genetics · 2018Article
- Use of theJournal of neurophysiology · 2017Review
- Memory of recent oxygen experience switches pheromone valence inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Consequences of degeneracy in network function.Current opinion in neurobiology · 2016Review
- Repetition priming of motor activity mediated by a central pattern generator: the importance of extrinsic vs. intrinsic program initiators.Journal of neurophysiology · 2016Article
- Sensory Cortical Activity Is Related to the Selection of a Rhythmic Motor Action Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Repetition priming-induced changes in sensorimotor transmission.Journal of neurophysiology · 2016Article
- Specificity of repetition priming: the role of chemical coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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2 authors.
Funding
Abstract
Behavioral states often preferentially enhance specific classes of behavior and suppress incompatible behaviors. In the nervous system, this may involve upregulation of the efficacy of neural modules that mediate responses to one stimulus and suppression of modules that generate antagonistic or incompatible responses to another stimulus. In Aplysia, prestimulation of egestive inputs [esophageal nerve (EN)] facilitates subsequent EN-elicited egestive responses and weakens ingestive responses to ingestive inputs [Cerebral-Buccal Interneuron (CBI-2)]. However, a single state can also promote incompatible behaviors in response to different stimuli. This is the case in Aplysia, where prestimulation of CBI-2 inputs not only enhances subsequent CBI-2-elicited ingestive responses, but also strengthens EN-elicited egestive responses. We used the modularly organized feeding network of Aplysia to characterize the organizational principles that allow a single network state to promote two opposing behaviors, ingestion and egestion, without the two interfering with each other. We found that the CBI-2 prestimulation-induced state upregulates the excitability of neuron B65 which, as a member of the egestive module, increases the strength of egestive responses. Furthermore, we found that this upregulation is likely mediated by the actions of the neuropeptides FCAP (Feeding Circuit Activating Peptide) and CP2 (Cerebral Peptide 2). This increased excitability is mediated by a form of modulation that we refer to as "latent modulation" because it is established during stimulation of CBI-2, which does not activate B65. However, when B65 is recruited into EN-elicited egestive responses, the effects of the latent modulation are expressed as a higher B65 firing rate and a resultant strengthening of the egestive response.
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