Evidence map›Paper›PMID 23447494›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2013

Rapid and specific post-synthesis modification of DNA through a biocompatible condensation of 1,2-aminothiols with 2-cyanobenzothiazole.

Yunfeng Cheng, Hanjing Peng, Weixuan Chen, Nanting Ni, Bowen Ke, Chaofeng Dai, Binghe Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yunfeng Cheng *Department of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098.
Hanjing Peng *Department of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098.
Weixuan ChenDepartment of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098.
Nanting NiDepartment of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098.
Bowen KeDepartment of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098.
Chaofeng DaiDepartment of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098.
Binghe WangDepartment of Chemistry, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098.
Georgia State University · US

Funding

Selection of Boronic Acid-modified Aptamers for GlycoproteinsR01GM084933 · NIGMS · GEORGIA STATE UNIVERSITY · PI WANG, BINGHE · 2008 to 2011
$1.2M
Aptamer-based Glycomics ToolsR42GM086925 · NIGMS · ECHELON BIOSCIENCES, INC. · PI WANG, BINGHE · 2009 to 2010
$555k
NIGMS NIH HHS GM084933NIGMS NIH HHS GM086925NIGMS NIH HHS R01 GM084933NIGMS NIH HHS R42 GM086925
6 · The paper itself

Abstract

Post-synthesis modification of DNA is an important way of functionalizing DNA molecules. Herein, we describe a method that first enzymatically incorporates a cyanobenzothiazole (CBT)-modified thymidine. The side-chain handle CBT can undergo a rapid and site-specific cyclization reaction with 1,2-aminothiols to afford DNA functionalization in aqueous solution. Another key advantage of this method is the formation of a single stereo/regioisomer in the process, which allows for precise control of DNA modification to yield a single component for aptamer selection work and other applications.

Indexed as

BenzothiazolesClick ChemistryCyclizationDNANitrilesSulfhydryl Compounds2-cyanobenzothiazoleBenzothiazolesDNANitrilesSulfhydryl Compounds

Identifiers

PMID23447494
PMCPMC3918485
OpenAlexW1996911631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.