ArticleSmall (Weinheim an der Bergstrasse, Germany)2013
Acute on-chip HIV detection through label-free electrical sensing of viral nano-lysate.
Article in Small (Weinheim an der Bergstrasse, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electronic and electrochemical viral detection for point-of-care use: A systematic review.PloS one · 2021Pooled it
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- A luminescence-based point-of-care HIV viral load test for antiretroviral therapy monitoring.Lab on a chip · 2025Article
- Nonlinear dynamics of in-plane ring resonator for mass sensing.Microsystem technologies : sensors, actuators, systems integration · 2025Article
- In situ synthesis and dynamic simulation of molecularly imprinted polymeric nanoparticles on a micro-reactor system.Nature communications · 2023Article
- A Review on Microfluidics-Based Impedance Biosensors.Biosensors · 2023Review
- Recent Advances in 3D Printing of Biomedical Sensing Devices.Advanced functional materials · 2022Article
- A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis.Biosensors · 2021Review
- Nano-engineered screen-printed electrodes: A dynamic tool for detection of viruses.Trends in analytical chemistry : TRAC · 2021Review
- Development of a Point-of-Care Assay for HIV-1 Viral Load Using Higher Refractive Index Antibody-Coated Microbeads.Sensors (Basel, Switzerland) · 2021Article
- Mobile Health (mHealth) Viral Diagnostics Enabled with Adaptive Adversarial Learning.ACS nano · 2021Article
- Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications.Sensors (Basel, Switzerland) · 2020Review
- Advances in Continuous Microfluidics-Based Technologies for the Study of HIV Infection.Viruses · 2020Review
- Thermal Shock Response of Yeast Cells Characterised by Dielectrophoresis Force Measurement.Sensors (Basel, Switzerland) · 2019Article
- Characterization of Simple and Double Yeast Cells Using Dielectrophoretic Force Measurement.Sensors (Basel, Switzerland) · 2019Article
- Rapid immunodiagnostics of multiple viral infections in an acoustic microstreaming device with serum and saliva samples.Lab on a chip · 2019Article
- A Comparison of Optical, Electrochemical, Magnetic, and Colorimetric Point-of-Care Biosensors for Infectious Disease Diagnosis.ACS infectious diseases · 2018Review
- Electromagnetic Nanoparticles for Sensing and Medical Diagnostic Applications.Materials (Basel, Switzerland) · 2018Review
- Point-of-care diagnostics to improve maternal and neonatal health in low-resource settings.Lab on a chip · 2017Review
- A microfluidic platform for drug screening in a 3D cancer microenvironment.Biosensors & bioelectronics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Development of portable biosensors has broad applications in environmental monitoring, clinical diagnosis, public health, and homeland security. There is an unmet need for pathogen detection at the point-of-care (POC) using a fast, sensitive, inexpensive, and easy-to-use method that does not require complex infrastructure and well-trained technicians. For instance, detection of Human Immunodeficiency Virus (HIV-1) at acute infection stage has been challenging, since current antibody-based POC technologies are not effective due to low concentration of antibodies. In this study, we demonstrated for the first time a label-free electrical sensing method that can detect lysed viruses, i.e. viral nano-lysate, through impedance analysis, offering an alternative technology to the antibody-based methods such as dipsticks and Enzyme-linked Immunosorbent Assay (ELISA). The presented method is a broadly applicable platform technology that can potentially be adapted to detect multiple pathogens utilizing impedance spectroscopy for other infectious diseases including herpes, influenza, hepatitis, pox, malaria, and tuberculosis. The presented method offers a rapid and portable tool that can be used as a detection technology at the POC in resource-constrained settings, as well as hospital and primary care settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.