Trial reportAnnals of neurology2013
Cholinergic enhancement of functional networks in older adults with mild cognitive impairment.
Trial report in Annals of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux.Nature communications · 2025Article
- The impact of cholinesterase inhibitors on cognitive trajectories in mild cognitive impairment patients based on amyloid beta status.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Integrity of the nucleus basalis of meynert and self-reported cognitive dysfunction during wearing-off periods in parkinson's disease.Brain imaging and behavior · 2024Article
- New perspectives on the basal forebrain cholinergic system in Alzheimer's disease.Neuroscience and biobehavioral reviews · 2023Review
- Choline and Fish Oil Can Improve Memory of Mice through Increasing Brain DHA Level.Foods (Basel, Switzerland) · 2023Article
- Neuromodulatory effects of high-definition theta transcranial alternating current stimulation on the parietal cortex: a pilot study of healthy males.Frontiers in neuroscience · 2023Article
- Altered Brain Activity in Depression of Parkinson's Disease: A Meta-Analysis and Validation Study.Frontiers in aging neuroscience · 2022Article
- Muscarinic Receptor-Dependent Long Term Depression in the Perirhinal Cortex and Recognition Memory are Impaired in the rTg4510 Mouse Model of Tauopathy.Neurochemical research · 2019Article
- Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Functional MRI technologies in the study of medication treatment effect on Alzheimer's disease.Aging medicine (Milton (N.S.W)) · 2018Review
- Effects of pharmacological and nonpharmacological treatments on brain functional magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment: a critical review.Alzheimer's research & therapy · 2018Review
- Advancing the Neurophysiological Understanding of Delirium.Journal of the American Geriatrics Society · 2017Article
- Effect of Pharmacological Interventions on the Fronto-Cingulo-Parietal Cognitive Control Network in Psychiatric Disorders: A Transdiagnostic Systematic Review of fMRI Studies.Frontiers in psychiatry · 2016Review
- Disposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects.Journal of cognitive neuroscience · 2014Article
- Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons.Brain connectivity · 2014Article
- Network dynamics predict improvement in working memory performance following donepezil administration in healthy young adults.NeuroImage · 2014Article
- Reliability measures of functional magnetic resonance imaging in a longitudinal evaluation of mild cognitive impairment.NeuroImage · 2014Article
- A cognitive framework for understanding and improving interference resolution in the brain.Progress in brain research · 2013Review
- Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment during Episodic Memory Encoding.Frontiers in psychiatry · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe importance of the cholinergic system for cognitive function has been well documented in animal and human studies. The objective of this study was to elucidate the cognitive and functional connectivity changes associated with enhanced acetylcholine levels. We hypothesized that older adults with mild memory deficits would show behavioral and functional network enhancements with an acetylcholinesterase inhibitor treatment (donepezil) when compared to a placebo control group.
methodsWe conducted a 3-month, double-blind, placebo-controlled study on the effects of donepezil in 27 older adults with mild memory deficits. Participants completed a delayed recognition memory task. Functional magnetic resonance imaging (fMRI) scans were collected at baseline prior to treatment and at 3-month follow-up while subjects were on a 10mg daily dose of donepezil or placebo.
resultsDonepezil treatment significantly enhanced the response time for face and scene memory probes when compared to the placebo group. A group-by-visit interaction was identified for the functional network connectivity of the left fusiform face area (FFA) with the hippocampus and inferior frontal junction, such that the treatment group showed increased connectivity over time when compared to the placebo group. Additionally, the enhanced functional network connectivity of the FFA and hippocampus significantly predicted memory response time at 3-month follow-up in the treatment group.
interpretationThese findings suggest that increased cholinergic transmission improves goal-directed neural processing and cognitive ability and may serve to facilitate communication across functionally-connected attention and memory networks. Longitudinal fMRI is a useful method for elucidating the neural changes associated with pharmacological modulation and is a potential tool for monitoring intervention efficacy in clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.