ArticleAdvanced healthcare materials2013
Unique antimicrobial effects of platelet-rich plasma and its efficacy as a prophylaxis to prevent implant-associated spinal infection.
Article in Advanced healthcare materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Systematic literature review evaluating evidence and mechanisms of action for platelet-rich plasma as an antibacterial agent.Journal of cardiothoracic surgery · 2021Pooled it
- Macroscopic Markers of Dolphin Healing at Sea Linked to Immunity.Animals : an open access journal from MDPI · 2026Article
- Article
- Platelet-rich therapies in cutaneous and mucocutaneous disorders characterized by inflammatory tissue responses: mechanistic insights and clinical evidence.Frontiers in medicine · 2026Review
- Antibacterial and antibiofilm activity of platelet-rich plasma under different activation conditions against multidrug-resistant MRSA isolated from human skin abscesses.BMC biotechnology · 2025Article
- Platelet-rich plasma attenuates the UPEC-induced cystitis via inhibiting MMP-2,9 activities and downregulation of NGF and VEGF in Canis Lupus Familiaris model.Scientific reports · 2024Article
- Evaluation of Platelet-Rich Plasma by means of PRGFFrontiers in veterinary science · 2023Article
- Intramammary treatment using allogeneic pure platelet-rich plasma in cows with subclinical mastitis caused by Gram-positive bacteria.Scientific reports · 2021Article
- An evaluation of the bacteriostatic effect of platelet-rich plasma.International wound journal · 2021Article
- Improved Bone Quality and Bone Healing of Dystrophic Mice by Parabiosis.Metabolites · 2021Article
- Antimicrobial Effects of Equine Platelet Lysate.Frontiers in veterinary science · 2021Article
- Antibacterial Properties of Canine Platelet-Rich Plasma and Other Non-Transfusional Hemo-Components: AnFrontiers in veterinary science · 2021Article
- Effects and mechanism of platelet-rich plasma on military drill injury: a review.Military Medical Research · 2020Review
- Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation.Tissue engineering. Part B, Reviews · 2019Review
- Platelet-rich plasma as an additional therapeutic option for infected wounds with multi-drug resistant bacteria: in vitro antibacterial activity study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019Article
- The efficacy of platelet-rich plasma gel in MRSA-related surgical wound infection treatment: an experimental study in an animal model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Article
- Bacteria antibiotic resistance: New challenges and opportunities for implant-associated orthopedic infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction.Molecular neurobiology · 2015Review
- Differential responses of osteoblasts and macrophages upon Staphylococcus aureus infection.BMC microbiology · 2014Article
- Platelets: at the nexus of antimicrobial defence.Nature reviews. Microbiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Platelet-rich-plasma (PRP) has attracted great attention and has been increasingly used for a variety of clinical applications including orthopedic surgeries, periodontal and oral surgeries, maxillofacial surgeries, plastic surgeries, and sports medicine. However, very little is known about the antimicrobial activities of PRP. PRP is found to have antimicrobial properties both in vitro and in vivo. In vitro, the antimicrobial properties of PRP are bacterial-strain-specific and time-specific: PRP significantly (80-100 fold reduction in colony-forming units) inhibits the growth of methicillin-sensitive and methicillin-resistant Staphylococcus aureus, Group A streptococcus, and Neisseria gonorrhoeae within the first few hours but it has no significant antimicrobial properties against E. coli and Pseudomonas. The antimicrobial properties of PRP also depend on the concentration of thrombin. In vivo, an implant-associated spinal infection rabbit model is established and used to evaluate the antimicrobial and wound-healing properties of PRP. Compared to the infection controls, PRP treatment results in significant reduction in bacterial colonies in bone samples at all time points studied (i.e. 1, 2, and 3 weeks) and significant increase in mineralized tissues (thereby better bone healing) at postoperative weeks 2 and 3. PRP therefore may be a useful adjunct strategy against postoperative implant-associated infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.