ReviewInflammopharmacology2013
Antibacterial and immunomodulatory properties of azithromycin treatment implications for periodontitis.
Review in Inflammopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Systemic benefits of periodontal therapy in patients with obesity and periodontitis: a systematic review.Brazilian oral research · 2024Pooled it
- Disease severity, debridement approach and timing of drug modify outcomes of adjunctive azithromycin in non-surgical management of chronic periodontitis: a multivariate meta-analysis.BMC oral health · 2019Pooled it
- Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs.Clinical oral investigations · 2015Pooled it
- Effects of long-term use of macrolides in patients with non-cystic fibrosis bronchiectasis: a meta-analysis of randomized controlled trials.BMC infectious diseases · 2015Pooled it
- Systemic Azithromycin as an Adjunct to Non-Surgical Subgingival Instrumentation in the Treatment of Stage III/IV, Grade C Periodontitis: 12-Month Clinical, Microbiological and Cytokine Results of a Randomised Controlled Trial.Journal of clinical periodontology · 2025Trial
- Use of amnion-derived cellular cytokine solution for the treatment of gingivitis: A 2-week safety, dose-ranging, proof-of-principle randomized trial.Journal of periodontology · 2021Trial
- Efficacy of regimens targeting Mycobacterium abscessus in vitro and in vivo.BMC microbiology · 2026Article
- Efficacy of carrimycin againstMicrobiology spectrum · 2025Article
- Azithromycin-loaded PLGA microspheres coated with silk fibroin ameliorate inflammation and promote periodontal tissue regeneration.Regenerative biomaterials · 2025Article
- Article
- Erythromycin Restores Osteoblast Differentiation and Osteogenesis Suppressed byPharmaceuticals (Basel, Switzerland) · 2023Article
- Azithromycin: Immunomodulatory and antiviral properties for SARS-CoV-2 infection.European journal of pharmacology · 2021Review
- Inhibition of neutrophil inflammatory mediator expression by azithromycin.Clinical oral investigations · 2020Article
- Comparing the Antimicrobial In Vitro Efficacy of Amoxicillin/Metronidazole against Azithromycin-A Systematic Review.Dentistry journal · 2018Review
- Effect of azithromycin on a red complex polymicrobial biofilm.Journal of oral microbiology · 2017Article
- Omega-3 fatty acids as an adjunct for periodontal therapy-a review.Clinical oral investigations · 2016Review
- Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro.Clinical oral investigations · 2015Article
- Advantages and drawbacks of long-term macrolide use in the treatment of non-cystic fibrosis bronchiectasis.Journal of thoracic disease · 2014Article
- Bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis.The American journal of pathology · 2013Article
- The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrolide antibiotics have been found to possess not only antimicrobial properties, but also modulate inflammation. In this review the multi-faceted properties of azithromycin are discussed. Due to the unique anti-inflammatory and antimicrobial properties, macrolides, and especially azithromycin, are currently used for a number of conditions which have both an inflammatory and microbial component. For the same reason, azithromycin may be of value as an adjunct in the management of periodontitis which, although driven by an infectious component, is largely a result of uncontrolled chronic inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.