ArticleThe American journal of clinical nutrition2013
One-carbon metabolism factors and leukocyte telomere length.
Article in The American journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The Effect of Alcohol on Telomere Length: A Systematic Review of Epidemiological Evidence and a Pilot Study during Pregnancy.International journal of environmental research and public health · 2021Pooled it
- Pooled it
- One-carbon metabolites and telomere length in a prospective and randomized study of B- and/or D-vitamin supplementation.European journal of nutrition · 2017Trial
- The effect of vitamin BTrials · 2017Trial
- Decreased cobalamin sensitivity and biological aging acceleration in the general population.The journal of nutrition, health & aging · 2024Article
- Review
- The Importance of Telomere Shortening for Atherosclerosis and Mortality.Journal of cardiovascular development and disease · 2020Review
- Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study.European journal of nutrition · 2020Article
- Micronutrient status and leukocyte telomere length in school-age Colombian children.European journal of nutrition · 2020Article
- Article
- Serum and Dietary Folate and Vitamin BOxidative medicine and cellular longevity · 2019Article
- Serum Folate, Vitamin B-12, Vitamin A, γ-Tocopherol, α-Tocopherol, and Carotenoids Do Not Modify Associations between Cadmium Exposure and Leukocyte Telomere Length in the General US Adult Population.The Journal of nutrition · 2017Article
- Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation.European journal of nutrition · 2016Article
- Leukocyte Telomere Length is Associated With Serum Vitamin B12 and Homocysteine Levels in Older Adults With the Presence of Systemic Inflammation.Clinical nutrition research · 2016Article
- High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort.European journal of nutrition · 2015Article
- Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study.Genes & nutrition · 2014Article
- The association between global DNA methylation and telomere length in a longitudinal study of boilermakers.Genetic epidemiology · 2014Article
- Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes.Journal of toxicology and environmental health. Part A · 2014Article
- The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDietary and genetic factors involved in the one-carbon metabolism pathway may affect telomere length through DNA methylation and synthesis, but this has not been comprehensively investigated in epidemiologic studies.
objectiveWe cross-sectionally examined associations between dietary and genetic factors in the one-carbon metabolism pathway and relative peripheral blood leukocyte telomere length.
designA total of 1715 participants from the Nurses' Health Study (NHS) had measurements of relative telomere length and plasma concentrations of folate, vitamin B-6, vitamin B-12, cysteine, and homocysteine. Food-frequency questionnaire (FFQ) measurements were also used for the assessment of folate, choline, methionine, riboflavin, vitamin B-6, vitamin B-12, and alcohol intakes. Genotyping was performed on 475 participants with telomere measurements on 29 mostly nonsynonymous single-nucleotide polymorphisms (SNPs) involved in one-carbon metabolism. Unconditional logistic and linear regression models were used.
resultsThere were no significant dose-response relations between any plasma- or FFQ-measured dietary factors and relative telomere length in multivariate analyses. For folate, vitamin B-6, and vitamin B-12, results from the use of FFQ data were consistent with plasma-biomarker findings. We showed no significant associations that involved SNPs and relative telomere length after we accounted for the false discovery rate.
conclusionOur analyses involving plasma and questionnaire measurements of one-carbon metabolism factors show that some key dietary and genetic factors in this metabolic network are not associated with relative peripheral blood leukocyte telomere length.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.