ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013
Associations of interleukin-6 with vegetative but not affective depressive symptoms in terminally ill cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Cancer-related inflammation and depressive symptoms: Systematic review and meta-analysis.Cancer · 2022Pooled it
- Associations between appetite loss and clinical features as well as inflammatory cytokines in adolescents with major depressive disorder.Frontiers in psychiatry · 2025Article
- Identification of Plasma Inflammatory Markers of Adolescent Depression Using the Olink Proteomics Platform.Journal of inflammation research · 2023Article
- Association of serum interleukin-6 and C-reactive protein with depressive and adjustment disorders in COVID-19 inpatients.Brain, behavior, & immunity - health · 2022Article
- Role of Interleukin-6 in Depressive Disorder.International journal of molecular sciences · 2020Review
- Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis.Scientific reports · 2019Observational
- Prevalence and relationship of malnutrition and distress in patients with Cancer using questionnaires.BMC cancer · 2018Article
- Cytokines and depression in cancer patients and caregivers.Neuropsychiatric disease and treatment · 2017Article
- Greater amygdala activity and dorsomedial prefrontal-amygdala coupling are associated with enhanced inflammatory responses to stress.Brain, behavior, and immunity · 2015Article
- Preoperative inflammatory biomarkers and neurovegetative symptoms in peritoneal carcinomatosis patients.Brain, behavior, and immunity · 2014Article
- Cytokine polymorphisms are associated with fatigue in adults living with HIV/AIDS.Brain, behavior, and immunity · 2014Article
- Article
- Performance of four diagnostic approaches to depression in adults with cancer.General hospital psychiatryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrevious studies have reported associations of depressive symptoms with pro-inflammatory cytokines, especially with interleukin-6 (IL-6) in noncancer subjects and cancer patients. Meanwhile, symptoms such as tiredness and appetite loss may be vegetative symptoms of depression when associated with other diagnostic criteria of depression. Such vegetative-type symptoms worsen during the last 6 months of life in cancer patients and may not be associated with affective depressive symptoms such as sadness and nervousness. This study explored associations between depressive symptoms and plasma IL-6 in terminally ill cancer patients whose survival period was confirmed to be less than 6 months by follow-up, with attention to differences in vegetative and affective depressive symptoms.
methodsData from 112 consecutively recruited terminally ill cancer patients who registered at a palliative care unit without any active anticancer treatment were used. Plasma IL-6 levels were measured using an electrochemiluminescence assay. Depressive symptoms included in the DSM-IV and Cavanaugh criteria were assessed by structured interviews and were categorized into affective symptoms and vegetative symptoms. Affective symptoms were also measured with the depression subscale of the Hospital Anxiety and Depression Scale, which does not include vegetative symptoms.
resultsVegetative symptoms, such as appetite loss, insomnia, and fatigue, were significantly associated with IL-6 levels. However, neither of the affective symptoms nor their severity was associated with IL-6 levels.
conclusionsIL-6 was associated with vegetative depressive symptoms in terminally ill cancer patients but not with affective depressive symptoms, suggesting possible differences in the pathophysiological mechanisms between these sets of symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.