ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2013
Association of Helicobacter pylori infection with inflammatory cytokine expression in patients with gallbladder cancer.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05789550 (HELICOBACTER PYLORI INFECTION IN TYPE 2 DIABETES MELLITUS IN ASSIUT UNIVERSITY HOSPITAL), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Helicobacter pylori infection in type 2 diabetes mellitus in assiut university hospital
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Overlapping cytokines inFrontiers in immunology · 2023Pooled it
- Risk Factors and Prognostic Factors in GBC.Journal of clinical medicine · 2024Review
- The footprint of gut microbiota in gallbladder cancer: a mechanistic review.Frontiers in cellular and infection microbiology · 2024Review
- Article
- Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China.Scientific reports · 2021Article
- Decipher the Helicobacter pylori Protein Targeting in the Nucleus of Host Cell and their Implications in Gallbladder Cancer: AnJournal of Cancer · 2021Article
- Prevalence and risk factors of gallbladder polyps in primary health care centers among patients examined by abdominal ultrasonography in Qatar: a case-control study.Qatar medical journal · 2021Article
- Relationship betweenThe Journal of international medical research · 2019Article
- Helicobacter pylori infection increases risk of incident metabolic syndrome and diabetes: A cohort study.PloS one · 2019Article
- Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles.Bioinformation · 2019Article
- The Interaction ofAdvanced biomedical research · 2019Review
- Plasma Helicobacter pylori Antibody Titers and Helicobacter pylori Infection Positivity Rates in Patients with Gallbladder Cancer or Cholelithiasis: a Hospital-Based Case-Control StudyAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population.Yonsei medical journal · 2016Article
- Lipopolysaccharide-pathway proteins are associated with gallbladder cancer among adults in Shanghai, China with mediation by systemic inflammation.Annals of epidemiology · 2016Article
- Helicobacter pylori in Cholecystectomy Specimens-Morphological and Immunohistochemical Assessment.Journal of clinical and diagnostic research : JCDR · 2016Article
- Helicobacter pylori infection and diabetes: is it a myth or fact?World journal of gastroenterology · 2014Review
- Helicobacter pylori infection prevalence: Is it different in diabetics and nondiabetics?Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimGallbladder cancer (GBC) may be associated with Helicobacter pylori. The present study was designed to analyze the association of cytokine expression with H. pylori in patients with GBC.
methodsGBC tissue sample and 5 mL blood were collected from each of 54 GBC patients. H. pylori was identified in tissue samples using biochemical tests, histology, culture, nested polymerase chain reaction (PCR), and partial genome sequencing. Tissue samples were categorized as H. pylori-positive (case) and H. pylori-negative groups (control) on the basis of nested PCR of tissue sample. Cytokines interleukin 1-β (IL-1β), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and interleukin-5 (IL-5) were assayed in blood samples using ELISA.
resultsPresence of H. pylori was confirmed in 18 (33 %) of 54 GBC tissue samples. Levels of IL-1β (p = 0.001) and TNF-α (p = 0.01) were significantly elevated in H. pylori-positive GBC compared to the control group. IFN-γ and IL-5 levels did not significantly differ between the two groups.
conclusionsH. pylori DNA was detected in the gallbladder of a third of GBC patients and was associated with higher circulating levels of some cytokines.
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