ArticleJournal of neurophysiology2013
Animal-to-animal variability in the phasing of the crustacean cardiac motor pattern: an experimental and computational analysis.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Conductance relationships across compartments associated with bursting output in a model of a motor neuron in the crustacean cardiac ganglion.Journal of neurophysiology · 2026Article
- Isoforms of the neuropeptide myosuppressin differentially modulate the cardiac neuromuscular system of the American lobster,Journal of neurophysiology · 2022Article
- Differential neuropeptide modulation of premotor and motor neurons in the lobster cardiac ganglion.Journal of neurophysiology · 2020Article
- The neuromuscular transform in a single segment of a segmented heart tube.Journal of neurophysiology · 2020Article
- Homeostatic plasticity of excitability in crustacean central pattern generator networks.Current opinion in neurobiology · 2017Review
- When complex neuronal structures may not matter.eLife · 2017Article
- Deep sequencing of transcriptomes from the nervous systems of two decapod crustaceans to characterize genes important for neural circuit function and modulation.BMC genomics · 2016Article
- There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes.Journal of molecular and cellular cardiology · 2016Article
- From global to local: exploring the relationship between parameters and behaviors in models of electrical excitability.Journal of computational neuroscience · 2016Article
- Motor neuronal activity varies least among individuals when it matters most for behavior.Journal of neurophysiology · 2015Article
- Article
- The neuromuscular transform of the lobster cardiac system explains the opposing effects of a neuromodulator on muscle output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
The cardiac ganglion (CG) of Homarus americanus is a central pattern generator that consists of two oscillatory groups of neurons: "small cells" (SCs) and "large cells" (LCs). We have shown that SCs and LCs begin their bursts nearly simultaneously but end their bursts at variable phases. This variability contrasts with many other central pattern generator systems in which phase is well maintained. To determine both the consequences of this variability and how CG phasing is controlled, we modeled the CG as a pair of Morris-Lecar oscillators coupled by electrical and excitatory synapses and constructed a database of 15,000 simulated networks using random parameter sets. These simulations, like our experimental results, displayed variable phase relationships, with the bursts beginning together but ending at variable phases. The model suggests that the variable phasing of the pattern has important implications for the functional role of the excitatory synapses. In networks in which the two oscillators had similar duty cycles, the excitatory coupling functioned to increase cycle frequency. In networks with disparate duty cycles, it functioned to decrease network frequency. Overall, we suggest that the phasing of the CG may vary without compromising appropriate motor output and that this variability may critically determine how the network behaves in response to manipulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.