ArticleProceedings. Biological sciences2013
Major urinary protein 5, a scent communication protein, is regulated by dietary restriction and subsequent re-feeding in mice.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Mup3 ameliorates the dysregulation of glucose and lipid metabolism in MAFLD.Acta pharmacologica Sinica · 2026Article
- Proteomic and phosphoproteomic signatures of aging mouse liver.GeroScience · 2025Article
- Intermittent fasting reduces inflammation and joint damage in a murine model of rheumatoid arthritis: insights from transcriptomic and metagenomic analyses.BMC rheumatology · 2024Article
- iTRAQ-Based Proteomic Profiling of Skin Aging Protective Effects ofMolecules (Basel, Switzerland) · 2024Article
- Major urinary protein (Microbiology spectrum · 2024Article
- The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research.Scientific reports · 2022Article
- Regulation of Sexually Dimorphic Expression of Major Urinary Proteins.Frontiers in physiology · 2022Review
- Caloric restriction delays age-related muscle atrophy by inhibiting 11β-HSD1 to promote the differentiation of muscle stem cells.Frontiers in medicine · 2022Article
- The Impact of Varying Food Availability on Gene Expression in the Liver: Testing the Match-Mismatch Hypothesis.Frontiers in nutrition · 2022Article
- Urinary protein analysis in mice lacking major urinary proteins.Experimental animals · 2021Article
- In Contrast to Dietary Restriction, Application of Resveratrol in Mice Does not Alter Mouse Major Urinary Protein Expression.Nutrients · 2020Article
- Immunochromatographic assay to detect α-tubulin in urine for the diagnosis of kidney injury.Journal of clinical laboratory analysis · 2020Article
- Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice.Scientific reports · 2019Article
- Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".Human genomics · 2019Review
- Regulation of volatile and non-volatile pheromone attractants depends upon male social status.Scientific reports · 2019Article
- Protein Restriction, Epigenetic Diet, Intermittent Fasting as New Approaches for Preventing Age-associated Diseases.International journal of preventive medicine · 2018Review
- Calorie restriction effects on circadian rhythms in gene expression are sex dependent.Scientific reports · 2017Article
- Diversity of major urinary proteins (MUPs) in wild house mice.Scientific reports · 2016Article
- Regulation of highly homologous major urinary proteins in house mice quantified with label-free proteomic methods.Molecular bioSystems · 2016Article
- The Presence Of Strange Males' Odor Induces Behavioral Responses And Elevated Levels Of Low Molecular Weight Proteins Excreted In The Urine Of Mature Water Vole Males (Arvicola amphibius L).Journal of chemical ecology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major urinary proteins (Mups) are important for rodent scent communication and sexual behaviour. Recent evidence suggests that Mup1 may be regulated by fasting and re-feeding (RF). However, other Mup isoforms are poorly investigated, and data on the impact of long-term dietary restriction (DR) and ad libitum RF on Mup expression are missing. We investigated the effects of long-term 25 per cent DR and subsequent RF on Mup expression in male C57BL6 mice. DR significantly decreased Mup gene expression, hepatic and urinary protein levels compared with ad libitum (AL) fed control mice, with the greatest downregulation found for Mup5 expression. The decline in Mup expression was inverted by six months of RF. Because of inhibitory glucocorticoid response elements in the genomic sequence of the Mup5 gene, the observed inverse correlation of nuclear glucocorticoid receptor levels with Mup expression in response to DR and subsequent RF is a possible regulatory mechanism. Additionally, gene-expression-inhibiting histone deacetylation (H3K9) occurred in the region of the Mup5 gene in response to DR. We assume that Mup may act as a molecular switch linking nutritional status to sexual behaviour of mice, and thereby regulating male fertility and reproduction in response to food supply.
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