ArticleProceedings. Biological sciences2013
A trade-off between oxidative stress resistance and DNA repair plays a role in the evolution of elevated mutation rates in bacteria.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Self-replicating artificial neural networks give rise to universal evolutionary dynamics.PLoS computational biology · 2024Article
- IsCurrent research in parasitology & vector-borne diseases · 2024Article
- Hypermutator emergence in experimentalEvolution letters · 2023Article
- Shifts from cooperative to individual-based predation defense determine microbial predator-prey dynamics.The ISME journal · 2023Article
- Chronic Ionizing Radiation of Plants: An Evolutionary Factor from Direct Damage to Non-Target Effects.Plants (Basel, Switzerland) · 2023Review
- Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.PLoS genetics · 2021Article
- Hidden paths to endless forms most wonderful: Complexity of bacterial motility shapes diversification of latent phenotypes.BMC evolutionary biology · 2020Article
- Adapting the engine to the fuel: mutator populations can reduce the mutational load by reorganizing their genome structure.BMC evolutionary biology · 2019Article
- Metabolic and proteomic alteration in phytohormone-producing endophytic Bacillus amyloliquefaciens RWL-1 during methanol utilization.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Hypermutation-induced in vivo oxidative stress resistance enhances Vibrio cholerae host adaptation.PLoS pathogens · 2018Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Temperature effects on life-history trade-offs, germline maintenance and mutation rate under simulated climate warming.Proceedings. Biological sciences · 2017Article
- Article
- Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model.BMC microbiology · 2017Article
- Darwinism for the Genomic Age: Connecting Mutation to Diversification.Frontiers in genetics · 2017Article
- Molecular mechanisms underlying the emergence of bacterial pathogens: an ecological perspective.Molecular plant pathology · 2016Review
- The properties of spontaneous mutations in the opportunistic pathogen Pseudomonas aeruginosa.BMC genomics · 2016Article
- Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model.PeerJ · 2016Article
- The SOS response increases bacterial fitness, but not evolvability, under a sublethal dose of antibiotic.Proceedings. Biological sciences · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dominant paradigm for the evolution of mutator alleles in bacterial populations is that they spread by indirect selection for linked beneficial mutations when bacteria are poorly adapted. In this paper, we challenge the ubiquity of this paradigm by demonstrating that a clinically important stressor, hydrogen peroxide, generates direct selection for an elevated mutation rate in the pathogenic bacterium Pseudomonas aeruginosa as a consequence of a trade-off between the fidelity of DNA repair and hydrogen peroxide resistance. We demonstrate that the biochemical mechanism underlying this trade-off in the case of mutS is the elevated secretion of catalase by the mutator strain. Our results provide, to our knowledge, the first experimental evidence that direct selection can favour mutator alleles in bacterial populations, and pave the way for future studies to understand how mutation and DNA repair are linked to stress responses and how this affects the evolution of bacterial mutation rates.
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Registered trials
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