ArticleCardiovascular diabetology2013
Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus.
Article in Cardiovascular diabetology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- General versus central adiposity as risk factors for cardiovascular-related outcomes in a high-risk population with type 2 diabetes: a post hoc analysis of the REWIND trial.Cardiovascular diabetology · 2023Trial
- Effects of analogue insulin in multiple daily injection therapy of type 2 diabetes on postprandial glucose control and cardiac function compared to human insulin: a randomized controlled long-term study.Cardiovascular diabetology · 2016Trial
- Development and Challenges of Pre-Heart Failure with Preserved Ejection Fraction.Reviews in cardiovascular medicine · 2023Review
- The impact of central obesity on the risk of hospitalization or death due to heart failure in type 1 diabetes: a 16-year cohort study.Cardiovascular diabetology · 2021Observational
- Association between Markers of Fibrosis and Heart Failure Incidence in Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2021Article
- The early effect of dapagliflozin on strain and tissue Doppler parameters of diastolic function in diabetic patients with heart failure with reduced ejection fraction.Archives of medical sciences. Atherosclerotic diseases · 2021Article
- Factors Associated with the Remission of Type 1 Diastolic Dysfunction after Dapagliflozin Treatment in Patients with Type 2 Diabetes.Journal of clinical medicine · 2020Article
- Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis.Clinical science (London, England : 1979) · 2019Review
- The Significance of the Effect of Visceral Adiposity on Left Ventricular Diastolic Function in the General Population.Scientific reports · 2019Article
- Potential impact of SGLT2 inhibitors on left ventricular diastolic function in patients with diabetes mellitus.Heart failure reviews · 2018Review
- Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease.Scientific reports · 2018Article
- Impact of overweight on left ventricular function in type 2 diabetes mellitus.Cardiovascular diabetology · 2017Article
- Changes of Virtual Planar QRS and T Vectors Derived from Holter in the Populations with and without Diabetes Mellitus.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2016Article
- Impact of long-term steroid therapy on epicardial and pericardial fat deposition: a cardiac MRI study.Cardiovascular diabetology · 2015Article
- Impaired fasting glucose and left ventricular diastolic dysfunction in middle-age adults: a retrospective cross-sectional analysis of 2971 subjects.Cardiovascular diabetology · 2015Article
- Cross-sectional analysis of serum calcium levels for associations with left ventricular hypertrophy in normocalcemia individuals with type 2 diabetes.Cardiovascular diabetology · 2015Article
- Clinical features of subclinical left ventricular systolic dysfunction in patients with diabetes mellitus.Cardiovascular diabetology · 2015Article
- Cardiac structure and function are altered in type 2 diabetes and non-alcoholic fatty liver disease and associate with glycemic control.Cardiovascular diabetology · 2015Article
- Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population.Cardiovascular diabetology · 2014Article
- Differential association of visceral adipose tissue with coronary plaque characteristics in patients with and without diabetes mellitus.Cardiovascular diabetology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe hypothesized that clinical factors other than glycemic control may influence abnormal cardiac function in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the independent factors for abnormal cardiac function among clinical factors in T2DM.
methodsWe studied 148 asymptomatic patients with T2DM without overt heart disease. Echocardiographic findings were compared between diabetic patients and 68 age-matched healthy subjects. Early (E) and late (A) diastolic mitral flow velocity and early diastolic mitral annular velocity (e') were measured for assessing left ventricular (LV) diastolic function. We evaluated insulin resistance, non-esterified fatty acid, high-sensitive CRP, estimated glomerular filtration rate, waist/hip ratio, abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and other clinical characteristics in addition to glycemic control. VAT and SAT were quantified by computed tomography.
resultsIn T2DM, E/A and e' were significantly lower, and E/e', left atrial volume and LV mass were significantly greater than in control subjects. In multivariate liner regression analysis, VAT was an independent determinant of left atrial volume (β =0.203, p=0.011), E/A (β =-0.208, p=0.002), e' (β =-0.354, p<0.001) and E/e' (β=0.220, p=0.003). Age was also an independent determinant, whereas fasting plasma glucose and hemoglobin A1c levels were not. In addition to systolic blood pressure, waist-hip ratio (β=0.173, p=0.024) and VAT/SAT ratio (β=0.162, p=0.049) were independent determinants of LV mass.
conclusionExcessive visceral fat accompanied by adipocyte dysfunction may play a greater role than glycemic control in the development of diastolic dysfunction and LV hypertrophy in T2DM.
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