ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2013
FDG PET-CT aids in the preoperative assessment of patients with newly diagnosed thymic epithelial malignancies.
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 102 citations in OpenAlex.
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- The valuable role of extended pleurectomy decortication and HITHOC for disseminated pleural thymoma.Mediastinum (Hong Kong, China) · 2024Article
- Superiority of [European journal of nuclear medicine and molecular imaging · 2023Article
- Imaging evaluation of thymic tumors.Mediastinum (Hong Kong, China) · 2023Review
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- Is PET/CT Able to Predict Histology in Thymic Epithelial Tumours? A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- The efficacy ofThe British journal of radiology · 2022Article
- Thymic Carcinomas-A Concise Multidisciplinary Update on Recent Developments From the Thymic Carcinoma Working Group of the International Thymic Malignancy Interest Group.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2022Review
- Outcomes of extended surgical resections for locally advanced thymic malignancies: a narrative review.Gland surgery · 2022Review
- Using CT to evaluate mediastinal great vein invasion by thymic epithelial tumors: measurement of the interface between the tumor and neighboring structures.European radiology · 2022Article
- Application of a combined radiomics nomogram based on CE-CT in the preoperative prediction of thymomas risk categorization.Frontiers in oncology · 2022Article
- Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies.Gland surgery · 2021Review
- Diagnostic and prognostic value of FDG PET-CT in patients with suspected recurrent thymic epithelial tumors.Scientific reports · 2021Article
- Micronodular thymic carcinoma with lymphoid hyperplasia: relevance of immunohistochemistry with a small panel of antibodies for diagnosis-a RYTHMIC study.Virchows Archiv : an international journal of pathology · 2021Article
- 18F-FDG PET/CT Evaluation of Thymomas: a Pictorial Review.Nuclear medicine and molecular imaging · 2021Article
- Advancement in Diagnostic Imaging of Thymic Tumors.Cancers · 2021Article
- Prognostic Significance of Metabolic Parameters byCancers · 2021Article
- 18F-FDG-PET/CT predicts grade of malignancy and invasive potential of thymic epithelial tumors.General thoracic and cardiovascular surgery · 2021Article
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7 authors at 1 institution in 1 country.
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Abstract
introductionAdvanced thymoma (stage III and IV) is difficult to detect by computed tomography (CT), yet it is important to distinguish between early (stage I and II) and advanced disease before surgery, as patients with locally advanced tumors require neoadjuvant chemotherapy to enable effective resection. This study assessed whether the amount of fluorodeoxyglucose (FDG) uptake can predict advanced thymoma and whether it can separate thymoma from thymic cancer.
methodsWe retrospectively reviewed FDG positron emission tomography (PET)-CT scans of 51 consecutive newly diagnosed patients with thymic epithelial malignancy. PET-CT findings documented focal FDG activity: SUVmax, SUVmean, SUVpeak, and total body volumetric standardized uptake value (SUV) measurements. These were correlated with Masaoka-Koga staging and World Health Organization classification. Wilcoxon ranked sum tests were used to assess association between SUV and pathological stage, cancer type, and classification.
resultsAmong the study patients, 37 had thymoma, 12 thymic carcinoma, and 2 thymic carcinoid. Higher focal FDG uptake was seen in patients with type B3 thymoma than in those with type A, AB, B1, or B2 thymoma (p < 0.006). FDG uptake was higher in patients with thymic carcinoma or carcinoid than in patients with thymoma (p < 0.0003), with more variable associations with volumetric SUV measurements. There was no significant association observed between higher focal FDG uptake and advanced-stage disease in thymoma patients (p > 0.09), although greater FDG-avid tumor volume was significantly associated with advanced disease (p < 0.03).
conclusionsFocal FDG uptake cannot predict advanced thymoma but is helpful in distinguishing thymoma from thymic carcinoma, or the more aggressive thymoma, type B3.
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