ArticleVirology journal2013
Analysis and mapping of a 3' coterminal transcription unit derived from human cytomegalovirus open reading frames UL30-UL32.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Contributions of the Human Cytomegalovirus UJournal of virology · 2021Article
- Identification and characterization of a novel group of natural anti-sense transcripts from RNA1.2 gene locus of human cytomegalovirus.Chinese medical journal · 2019Article
- Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection.Journal of virology · 2017Article
- A cluster of 3' coterminal transcripts from US12-US17 locus of human cytomegalovirus.Virus genes · 2016Article
- Functional annotation of human cytomegalovirus gene products: an update.Frontiers in microbiology · 2014Review
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Authors and funding
10 authors.
Funding
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Abstract
backgroundIt has been predicted that the UL31 gene originates from the positive strand of the human cytomegalovirus (HCMV) genome, whereas the UL30 and UL32 genes originate from the complementary strand. Except for the UL32 gene, the transcription of this gene region has not been investigated extensively.
methodsNorthern blotting, cDNA library screening, RACE-PCR,and RT-PCR were used.
resultsAt least eight transcripts of the antisense orientation of UL31 were transcribed from the UL30-UL32 region during the late phase of HCMV infection. The 3' coterminus of these transcripts was located within the predicted UL30 gene. The longest 6.0-kb transcript was initiated upstream of the predicted UL32 gene. Other transcripts were derived from the predicted UL30 and UL31 gene region. Except for the previously predicted UL32 open reading frame (ORF), three novel ORFs, named UL31anti-1, UL31anti-2 and UL31anti-3, were located in the transcripts from the UL31anti-UL32 transcription unit. No transcription was found in UL31.
conclusionA family of novel 3' coterminal transcripts was transcribed from the UL30-UL32 gene region.
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