ArticleBMC pregnancy and childbirth2013
Transgenerational programming of maternal behaviour by prenatal stress.
Article in BMC pregnancy and childbirth, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 71 citations in OpenAlex.
- Different early-life adversity paradigms have disparate effects on maternal care, neuronal activation, and social behavior in developing mice.Neurobiology of stress · 2026Article
- MRI-based structural development of the human newborn hypothalamus.Developmental cognitive neuroscience · 2026Article
- Effects of Maternal and Cumulative Stress on Immune Phenotype and Stress Reactivity in Sows Later in Life.Animals : an open access journal from MDPI · 2026Article
- Toward Understanding and Halting Legacies of Trauma.Biological psychiatry · 2025Review
- Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations.Communications biology · 2025Article
- Maternal stress effects across generations in a precocial bird.Royal Society open science · 2024Article
- Legacies of salient environmental experiences-insights from chemosensation.Chemical senses · 2024Article
- Effects of maternal social isolation on adult rodent offspring cognition.Scientific reports · 2023Article
- Maternal Behavior in Beef Cattle: The Physiology, Assessment and Future Directions-A Review.Veterinary sciences · 2022Review
- Social Isolation Stress Modulates Pregnancy Outcomes and the Inflammatory Profile of Rat Uterus.International journal of molecular sciences · 2022Article
- Climate change is a major stressor causing poor pregnancy outcomes and child development.F1000Research · 2020Review
- Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice.Frontiers in immunology · 2020Article
- Ancestral Stress Alters Lifetime Mental Health Trajectories and Cortical Neuromorphology via Epigenetic Regulation.Scientific reports · 2019Article
- Review
- Prenatal two-hit stress affects maternal and offspring pregnancy outcomes and uterine gene expression in rats: match or mismatch?Biology of reproduction · 2019Article
- Intergenerational Sex-Specific Transmission of Maternal Social Experience.Scientific reports · 2018Article
- Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain.Oncotarget · 2018Article
- Prenatal noise stress impairs HPA axis and cognitive performance in mice.Scientific reports · 2017Article
- Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study.Translational psychiatry · 2017Article
- Intergenerational accumulation of impairments in maternal behavior following postnatal social stress.Psychoneuroendocrinology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Peripartum events hold the potential to have dramatic effects in the programming of physiology and behaviour of offspring and possibly subsequent generations. Here we have characterized transgenerational changes in rat maternal behaviour as a function of gestational and prenatal stress. Pregnant dams of the parental generation were exposed to stress from days 12-18 (F0-S). Their daughters and grand-daughters were either stressed (F1-SS, F2-SSS) or non-stressed (F1-SN, F2-SNN). Maternal antepartum behaviours were analyzed at a time when pregnant dams usually show a high frequency of tail chasing behaviours. F1-SS, F2-SNN and F2-SSS groups showed a significant reduction in tail chasing behaviours when compared with controls. The effects of multigenerational stress (SSS) slightly exceeded those of transgenerational stress (SNN) and resulted in absence of tail chasing behaviour. These findings suggest that antepartum maternal behaviour in rats is programmed by transgenerational inheritance of stress responses. Thus, altered antepartum maternal behaviour may serve as an indicator of an activated stress response during gestation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.