ArticleBiomacromolecules2013
Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates.
Article in Biomacromolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Synergistic anticancer effects of carrier-free self-assembled doxorubicin and emodin nanoparticles in non-small cell lung cancer.Scientific reports · 2025Article
- Functional Polyesters: Tailoring Structure and Biomedical Functions.Polymer science & technology (Washington, D.C.) · 2025Review
- Zero-Order Kinetics Release of Lamivudine from Layer-by-Layer Coated Macromolecular Prodrug Particles.International journal of molecular sciences · 2024Article
- Polymeric encapsulation of a ruthenium(ii) polypyridyl complex: from synthesis toChemical science · 2023Article
- Degradation of Polymer-Drug Conjugate Nanoparticles Based on Lactic and Itaconic Acid.International journal of molecular sciences · 2022Article
- Synergistic inhibition of metastatic breast cancer by dual-chemotherapy with excipient-free rhein/DOX nanodispersions.Journal of nanobiotechnology · 2020Article
- Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization.Chemical science · 2018Article
- Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach.Acta pharmaceutica Sinica. B · 2018Article
- Albumin as a "Trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting.Biomaterials science · 2018Article
- Stereoselective photoredox ring-opening polymerization of O-carboxyanhydrides.Nature communications · 2018Article
- Living Ring-Opening Polymerization ofFrontiers in chemistry · 2018Review
- Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes.Journal of visualized experiments : JoVE · 2017Article
- Drug-Initiated Synthesis of Polymer Prodrugs: Combining Simplicity and Efficacy in Drug Delivery.Chemistry of materials : a publication of the American Chemical Society · 2016Review
- Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.Biomaterials science · 2015Article
- Bioorthogonal Oxime Ligation MediatedChemical science · 2015Article
- Biodegradable micelles capable of mannose-mediated targeted drug delivery to cancer cells.Macromolecular rapid communications · 2015Article
- Ring-opening polymerization of L-lactic acid O-carboxyanhydrides initiated by alkoxy rare earth compounds.Molecules (Basel, Switzerland) · 2013Article
- Anticancer Camptothecin-Polymer chemistryArticle
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
We report a novel synthetic strategy of polymer-drug conjugates for nanoparticulate drug delivery: hydroxyl-containing drug (e.g., camptothecin, paclitaxel, doxorubicin and docetaxel) can initiate controlled polymerization of phenyl O-carboxyanhydride (Phe-OCA) to afford drug-poly(Phe-OCA) conjugated nanoparticles, termed drug-PheLA nanoconjugates (NCs). Our new NCs have well-controlled physicochemical properties, including high drug loading, quantitative drug loading efficiency, controlled particle size with narrow particle size distribution, and sustained drug release profile over days without "burst" release effect as observed in conventional polymer/drug encapsulates. Compared with polylactide NCs, the PheLA NCs have increased noncovalent hydrophobic interchain interactions and thereby result in remarkable stability in human serum with negligible particle aggregation. Such distinctive properties can reduce the premature disassembly of NCs upon dilution in the bloodstream and prolong NCs' in vivo circulation with the enhancement of intratumoral accumulation of NCs, which has a bearing on therapeutic effectiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.