ArticleThe journal of physical chemistry. B2013
Solution NMR and computational methods for understanding protein allostery.
Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase.Nature communications · 2023Article
- A Time-Dependent Quantum Approach to Allostery and a Comparison With Light-Harvesting in Photosynthetic Phenomenon.Frontiers in molecular biosciences · 2020Article
- Exploring Allosteric Pathways of a V-Type Enzyme with Dynamical Perturbation Networks.The journal of physical chemistry. B · 2019Article
- Self-organization, entropy and allostery.Biochemical Society transactions · 2018Review
- Site-Mutation of Hydrophobic Core Residues Synchronically Poise Super Interleukin 2 for Signaling: Identifying Distant Structural Effects through Affordable Computations.International journal of molecular sciences · 2018Article
- Glutamine Hydrolysis by Imidazole Glycerol Phosphate Synthase Displays Temperature Dependent Allosteric Activation.Frontiers in molecular biosciences · 2018Article
- Applications of NMR and computational methodologies to study protein dynamics.Archives of biochemistry and biophysics · 2017Review
- Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Allosteric Communication Disrupted by a Small Molecule Binding to the Imidazole Glycerol Phosphate Synthase Protein-Protein Interface.Biochemistry · 2016Article
- Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Dissecting Dynamic Allosteric Pathways Using Chemically Related Small-Molecule Activators.Structure (London, England : 1993) · 2016Article
- Protein Allostery and Conformational Dynamics.Chemical reviews · 2016Review
- Rigid Residue Scan Simulations Systematically Reveal Residue Entropic Roles in Protein Allostery.PLoS computational biology · 2016Article
- NMR Methods to Study Dynamic Allostery.PLoS computational biology · 2016Review
- Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex.Scientific reports · 2016Article
- Biophysical and computational methods to analyze amino acid interaction networks in proteins.Computational and structural biotechnology journal · 2016Review
- Information flow and protein dynamics: the interplay between nuclear magnetic resonance spectroscopy and molecular dynamics simulations.Frontiers in plant science · 2015Review
- The ensemble nature of allostery.Nature · 2014Review
- Local packing modulates diversity of iron pathways and cooperative behavior in eukaryotic and prokaryotic ferritins.The Journal of chemical physics · 2014Article
- Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase.Archives of biochemistry and biophysics · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Allosterism is an essential biological regulatory mechanism. In enzymes, allosteric regulation results in an activation or inhibition of catalytic turnover. The mechanisms by which this is accomplished are unclear and vary significantly depending on the enzyme. It is commonly the case that a metabolite binds to the enzyme at a site distant from the catalytic site, yet its binding is coupled to and sensed by the active site. This coupling can manifest in changes in structure, dynamics, or both at the active site. These interactions between the allosteric and active site, which are often quite distant from one another, involve numerous atoms as well as complex conformational rearrangements of the protein secondary and tertiary structure. Interrogation of this complex biological phenomenon necessitates multiple experimental approaches. In this article, we outline a combined solution NMR spectroscopic and computational approach using molecular dynamics and network models to uncover mechanistic aspects of allostery in the enzyme imidazole glycerol phosphate synthase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.