Evidence map›Paper›PMID 23445056›Full record

ReviewJournal of biomechanical engineering2013

Biochemomechanics of intraluminal thrombus in abdominal aortic aneurysms.

J S Wilson, L Virag, P Di Achille, I Karsaj, J D Humphrey

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of biomechanical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 102 citations in OpenAlex.

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  19. Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images.International journal of computer assisted radiology and surgery · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

J S WilsonDepartment of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
L Virag
P Di Achille
I Karsaj
J D Humphrey
Yale University · USUniversity of Zagreb · HR

Funding

Biomechanical Simulation of Evolving Aortic Aneurysms for Designing InterventionR01HL086418 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D. · 2008 to 2017
$3.8M
Gender Specific Evolution of Abdominal Aortic Aneurysm Composition and PropertiesR21HL107768 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D. · 2012 to 2013
$421k
NHLBI NIH HHS HL086418NHLBI NIH HHS R01 HL086418NHLBI NIH HHS R21 HL107768
6 · The paper itself

Abstract

Most computational models of abdominal aortic aneurysms address either the hemodynamics within the lesion or the mechanics of the wall. More recently, however, some models have appropriately begun to account for the evolving mechanics of the wall in response to the changing hemodynamic loads. Collectively, this large body of work has provided tremendous insight into this life-threatening condition and has provided important guidance for current research. Nevertheless, there has yet to be a comprehensive model that addresses the mechanobiology, biochemistry, and biomechanics of thrombus-laden abdominal aortic aneurysms. That is, there is a pressing need to include effects of the hemodynamics on both the development of the nearly ubiquitous intraluminal thrombus and the evolving mechanics of the wall, which depends in part on biochemical effects of the adjacent thrombus. Indeed, there is increasing evidence that intraluminal thrombus in abdominal aortic aneurysms is biologically active and should not be treated as homogeneous inert material. In this review paper, we bring together diverse findings from the literature to encourage next generation models that account for the biochemomechanics of growth and remodeling in patient-specific, thrombus-laden abdominal aortic aneurysms.

Indexed as

Mechanical PhenomenaAnimalsAortic Aneurysm, AbdominalBiomechanical PhenomenaHumansModels, BiologicalThrombosis

Identifiers

PMID23445056
PMCPMC3705799
OpenAlexW1980020427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.