Evidence map›Paper›PMID 23445046›Full record

ReviewJournal of biomechanical engineering2013

Evolving strategies in mechanobiology to more effectively treat damaged musculoskeletal tissues.

David L Butler, Nathaniel A Dyment, Jason T Shearn, Kirsten R C Kinneberg, Andrew P Breidenbach, Andrea L Lalley, Steven D Gilday, Cynthia Gooch, M B Rao, Chia-feng Liu and 1 more

Abstract readReview
In one paragraph

Review in Journal of biomechanical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. A brief history of tendon and ligament bioreactors: Impact and future prospects.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  2. Tendon healing in the context of complex fractures.Clinical reviews in bone and mineral metabolism · 2018
    Article
  3. Scaffolds for tendon and ligament repair and regeneration.Annals of biomedical engineering · 2015
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

David L ButlerTissue Engineering and Biomechanics Laboratories, Biomedical Engineering Program, College of Engineering and Applied Sciences, University of Cincinnati; Cincinnati, OH 45221, USA. david.butler@uc.edu
Nathaniel A Dyment
Jason T Shearn
Kirsten R C Kinneberg
Andrew P Breidenbach
Andrea L Lalley
Steven D Gilday
Cynthia Gooch
M B Rao
Chia-feng Liu
Christopher Wylie
University of Cincinnati · USCincinnati Children's Hospital Medical Center · USUConn Health · USUniversity of Cincinnati Medical Center · USUniversity of Colorado Boulder · US

Funding

Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
In Vitro Mechanical Stimulation to Enhance Tendon RepairR01AR046574 · NIAMS · UNIVERSITY OF CINCINNATI · PI BUTLER, DAVID L · 2000 to 2009
$3.5M
A Developmentally-Based Tissue Engineering Approach to Improve Tendon RepairR01AR056943 · NIAMS · UNIVERSITY OF CINCINNATI · PI SHEARN, JASON T · 2009 to 2013
$3.3M
Establishing Design Criteria and Large Animal Model for Evaluation of ACL RepairR01AR056660 · NIAMS · UNIVERSITY OF CINCINNATI · PI SHEARN, JASON T · 2010 to 2013
$1.3M
HUMAN AND MURINE MODELS OF TYPE V COLLAGEN DEFICIENCYR01AR047054 · NIAMS · CHILDREN'S HOSPITAL MED CTR (CINCINNATI) · PI WENSTRUP, RICHARD J. · 2000 to 2003
$1.1M
Cell phenotype-controlled mechanical signaling of MSCsR21EB002361 · NIBIB · UNIVERSITY OF CINCINNATI · PI BUTLER, DAVID L · 2003 to 2004
$422k
Robotic Simulation: Tissue Function with In Vivo MotionsR21EB004859 · NIBIB · UNIVERSITY OF CINCINNATI · PI BUTLER, DAVID L · 2006 to 2007
$396k
NIAMS NIH HHS AR46574NIAMS NIH HHS AR47054NIAMS NIH HHS AR56660NIAMS NIH HHS AR56943NIAMS NIH HHS R01 AR046574NIAMS NIH HHS R01 AR047054NIAMS NIH HHS R01 AR056660NIAMS NIH HHS R01 AR056943NIBIB NIH HHS EB002361NIBIB NIH HHS EB004859NIBIB NIH HHS R21 EB002361NIBIB NIH HHS R21 EB004859NIGMS NIH HHS T32 GM 063483NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

In this paper, we had four primary objectives. (1) We reviewed a brief history of the Lissner award and the individual for whom it is named, H.R. Lissner. We examined the type (musculoskeletal, cardiovascular, and other) and scale (organism to molecular) of research performed by prior Lissner awardees using a hierarchical paradigm adopted at the 2007 Biomechanics Summit of the US National Committee on Biomechanics. (2) We compared the research conducted by the Lissner award winners working in the musculoskeletal (MS) field with the evolution of our MS research and showed similar trends in scale over the past 35 years. (3) We discussed our evolving mechanobiology strategies for treating musculoskeletal injuries by accounting for clinical, biomechanical, and biological considerations. These strategies included studies to determine the function of the anterior cruciate ligament and its graft replacements as well as novel methods to enhance soft tissue healing using tissue engineering, functional tissue engineering, and, more recently, fundamental tissue engineering approaches. (4) We concluded with thoughts about future directions, suggesting grand challenges still facing bioengineers as well as the immense opportunities for young investigators working in musculoskeletal research. Hopefully, these retrospective and prospective analyses will be useful as the ASME Bioengineering Division charts future research directions.

Indexed as

Mechanical PhenomenaAnimalsAwards and PrizesBiologyBiomechanical PhenomenaHumansMusculoskeletal SystemSpatio-Temporal Analysis

Identifiers

PMID23445046
PMCPMC3703646
OpenAlexW1963607805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.