ArticleThe Journal of endocrinology2013
Acute psychological stress results in the rapid development of insulin resistance.
Article in The Journal of endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 99 citations in OpenAlex.
- Trial
- Effects of a mindfulness-based weight loss intervention in adults with obesity: A randomized clinical trial.Obesity (Silver Spring, Md.) · 2016Trial
- Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments.Journal of translational medicine · 2015Trial
- Metformin-associated lactic acidosis during flood-related healthcare disruption in southern Thailand, 2025: a case series.Tropical medicine and health · 2026Article
- Gender differences in clinical correlates of glucose disturbance in patients with first-episode and drug-naïve major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- Neural Regulation of Blood Glucose in Acute Stress: A Report on Research Supported by Pathway to Stop Diabetes.Diabetes · 2026Review
- Review
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Differential contributions of cardiovascular health-related lifestyle factors to epigenetic ageing: implications for healthy longevity.BMC medicine · 2025Article
- Insulin-like Growth Factor 1 Impact on Alzheimer's Disease: Role in Inflammation, Stress, and Cognition.Current issues in molecular biology · 2025Review
- Prospective associations between psychosocial stress and the risk of type 2 diabetes in middle-aged adults: findings from the KoGES_CAVAS.Epidemiology and health · 2025Article
- The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson's Disease.International journal of molecular sciences · 2024Review
- Prevalence of dyslipidaemia within Polish nurses. Cross-sectional study - single and multiple linear regression models and ROC analysis.BMC public health · 2024Article
- Can eggshells indicate stressor exposure in free-range laying hens?Animal welfare (South Mimms, England) · 2024Article
- The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study.Journal of clinical medicine · 2023Article
- Differences in hospitalizations associated with severe COVID-19 disease among foreign- and Swedish-born.European journal of public health · 2023Article
- Levels of actigraphy-derived physical activity among Polish nurses: factors associated with the prevalence of selected metabolic disorders.Frontiers in public health · 2023Article
- Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae.Heliyon · 2022Review
- Food insecurity, diabetes, and perceived diabetes self-management among Latinos in California: Differences by nativity and duration of residence.Preventive medicine reports · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In recent years, the roles of chronic stress and depression as independent risk factors for decreased insulin sensitivity and the development of diabetes have been increasingly recognized. However, an understanding of the mechanisms linking insulin resistance and acute psychological stress are very limited. We hypothesized that acute psychological stress may cause the development of insulin resistance, which may be a risk factor in developing type 2 diabetes. We tested the hypothesis in a well-established mouse model using 180 episodes of inescapable foot shock (IES) followed by a behavioral escape test. In this study, mice that received IES treatment were tested for acute insulin resistance by measuring glucose metabolism and insulin signaling. When compared with normal and sham mice, mice that were exposed to IES resulting in escape failure (defined as IES with behavioral escape failure) displayed elevated blood glucose levels in both glucose tolerance and insulin tolerance tests. Furthermore, mice with IES exposure and behavioral escape failure exhibited impaired hepatic insulin signaling via the insulin-induced insulin receptor/insulin receptor substrate 1/Akt pathway, without affecting similar pathways in skeletal muscle, adipose tissue, and brain. Additionally, a rise in the murine growth-related oncogene KC/GRO was associated with impaired glucose metabolism in IES mice, suggesting a mechanism by which psychological stress by IES may influence glucose metabolism. The present results indicate that psychological stress induced by IES can acutely alter hepatic responsiveness to insulin and affect whole-body glucose metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.