ArticleDevelopment (Cambridge, England)2013
Matrix adhesion polarizes heart progenitor induction in the invertebrate chordate Ciona intestinalis.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Investigating cellular dynamics in tunicates.Genesis (New York, N.Y. : 2000) · 2023Article
- Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor.PLoS biology · 2021Article
- Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors.Nature communications · 2019Article
- Review
- Dynamic interplay of cell fate, polarity and force generation in ascidian embryos.Current opinion in genetics & development · 2018Review
- An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time.eLife · 2018Article
- Transgenic Techniques for Investigating Cell Biology During Development.Advances in experimental medicine and biology · 2018Review
- Article
- Regulation and evolution of cardiopharyngeal cell identity and behavior: insights from simple chordates.Current opinion in genetics & development · 2015Review
- Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration.Development (Cambridge, England) · 2015Article
- Quantitative and in toto imaging in ascidians: working toward an image-centric systems biology of chordate morphogenesis.Genesis (New York, N.Y. : 2000) · 2015Review
- Heart genetics in a small package, exploiting the condensed genome of Ciona intestinalis.Briefings in functional genomics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cell-matrix adhesion strongly influences developmental signaling. Resulting impacts on cell migration and tissue morphogenesis are well characterized. However, the in vivo impact of adhesion on fate induction remains ambiguous. Here, we employ the invertebrate chordate Ciona intestinalis to delineate an essential in vivo role for matrix adhesion in heart progenitor induction. In Ciona pre-cardiac founder cells, invasion of the underlying epidermis promotes localized induction of the heart progenitor lineage. We found that these epidermal invasions are associated with matrix adhesion along the pre-cardiac cell/epidermal boundary. Through targeted manipulations of RAP GTPase activity, we were able to manipulate pre-cardiac cell-matrix adhesion. Targeted disruption of pre-cardiac cell-matrix adhesion blocked heart progenitor induction. Conversely, increased matrix adhesion generated expanded induction. We were also able to selectively restore cell-matrix adhesion and heart progenitor induction through targeted expression of Ci-Integrin β2. These results indicate that matrix adhesion functions as a necessary and sufficient extrinsic cue for regional heart progenitor induction. Furthermore, time-lapse imaging suggests that cytokinesis acts as an intrinsic temporal regulator of heart progenitor adhesion and induction. Our findings highlight a potentially conserved role for matrix adhesion in early steps of vertebrate heart progenitor specification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.