ArticleCroatian medical journal2013
Abnormal circadian rhythm and cortisol excretion in autistic children: a clinical study.
Article in Croatian medical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Biological correlates of altered circadian rhythms, autonomic functions and sleep problems in autism spectrum disorder.Annals of general psychiatry · 2022Review
- Zen shiatsu: a longitudinal case study measuring stress reduction in a child with autism spectrum disorder.International journal of therapeutic massage & bodywork · 2014Article
- Marked elevation of adrenal steroids, especially androgens, in saliva of prepubertal autistic children.European child & adolescent psychiatry · 2014Article
- A novel automated behavioral test battery assessing cognitive rigidity in two genetic mouse models of autism.Frontiers in behavioral neuroscience · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the circadian rhythm alteration of cortisol excretion and the level of corticosteroids in children with different grades of autism severity.
methodsThe study included 45 children with different grades of autism severity (low [LFA], medium [MFA], and high functioning autism [HFA]), 15 in each group, and 45 age/sex-matched children with typical development. The urinary levels of free cortisol (at three phases of 24-hour cycle), corticosteroids, vanilylmandelic acid, and 5-hydroxyindole acetic acid were determined.
resultsAlteration in the pattern of cortisol excretion (Phases I, II, and III) was observed in children with LFA (Phase I: 43.8 ± 4.43 vs 74.30 ± 8.62, P=0.000; Phase II: 21.1 ± 2.87 vs 62 ± 7.68, P<0.001; Phase III: 9.9 ± 1.20 vs 40 ± 5.73, P<0.001) and MFA (Phase I: 43.8 ± 4.43 vs 52.6 ± 7.90, P<0.001; Phase II: 21.1 ± 2.87 vs 27.4 ± 4.05, P<0.001; Phase III: 9.9 ± 1.20 vs 19 ± 2.50, P<0.001) compared to the control group. The corticosteroids excretion levels were higher in all the groups of children with autism than in the control group. The level of 5-hydroxyindole acetic acid was significantly higher in children with LFA (8.2 ± 1.48 vs 6.8 ± 0.85, P<0.001) and MFA (8.2 ± 1.48 vs 7.4 ± 0.89, P=0.001) and not significantly higher in children with HFA than in the control group. The changes were correlated with degrees of severity of the disorder.
conclusionThese data suggest that altered cortisol excretion pattern and high level of corticosteroids in urine may probably be a consequence of altered hypothalamic-pituitary-adrenal axis function, which may contribute to the pathogenesis and affect the severity of autism.
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