Evidence map›Paper›PMID 23444214›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2013

Zoom Zoom: racing CARs for multiple myeloma.

Marcela V Maus, Carl H June

Abstract readComment
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  11. CARs and other T cell therapies for MM: The clinical experience.Best practice & research. Clinical haematology · 2018
    Review
  12. Review
  13. Review
  14. Cellular and vaccine immunotherapy for multiple myeloma.Hematology. American Society of Hematology. Education Program · 2016
    Review
  15. Review
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  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marcela V MausTranslational Research Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. mausm@uphs.upenn.edu
Carl H June
University of Pennsylvania · US

Funding

Designer antigen receptors to re-direct T cells to the NY-ESO-1 tumor antigenK08CA166039 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MAUS, MARCELA VALDERRAMA · 2012 to 2016
$747k
NCI NIH HHS K08 CA166039
6 · The paper itself

Abstract

Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma.

Indexed as

AnimalsB-Cell Maturation AntigenHumansMultiple MyelomaReceptors, Antigen, T-CellT-LymphocytesB-Cell Maturation AntigenReceptors, Antigen, T-Cell

Identifiers

PMID23444214
PMCPMC3630266
OpenAlexW2153952179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.