Evidence map›Paper›PMID 23444198›Full record

ReviewJournal of cellular biochemistry2013

Cellular control of connective tissue matrix tension.

Helene M Langevin, Maiken Nedergaard, Alan K Howe

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02889991 (Comparative Study, Between Dry Needling Techniques, in the Evolution of Myofascial Pain Shoulder in Athletes. Elastography as Indicator in the Repair of Myofascial Tissue, Post-dry Needling.), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02889991 nacompletednot on this mapstarted 2016, after this paper: background citation

Comparative Study, Between Dry Needling Techniques, in the Evolution of Myofascial Pain Shoulder in Athletes. Elastography as Indicator in the Repair of Myofascial Tissue, Post-dry Needling.

TypeinterventionalSponsorUniversity of the Basque Country (UPV/EHU)Ran2016 to 2017Enrolled77ConditionsMyofascial Pain Syndromes, Dry Needling, Technique for the Treatment of the Myofascial Trigger Points, ElastographyArmsHigh Intensity Dry Needling, Low intensity Dry Needling, Fascial Mechanotransduction Dry Needling, Technique Placebo of Dry Needling
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
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  15. Review
  16. Fluid transport in the brain.Physiological reviews · 2022
    Review
  17. Review
  18. Furnishing Wound Repair by the Subcutaneous Fascia.International journal of molecular sciences · 2021
    Review
  19. A Complementary Intervention to Promote Wellbeing and Stress Management for Early Career Teachers.International journal of environmental research and public health · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Helene M LangevinDepartment of Neurological Sciences, Vermont Cancer Center, University of Vermont, Burlington, Vermont, USA. helene.langevin@uvm.edu
Maiken Nedergaard
Alan K Howe
University of Vermont · USUniversity of Rochester · US

Funding

Connective Tissue MechanotransductionR01AT001121 · NCCIH · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI LANGEVIN, HELENE M · 2002 to 2012
$3.7M
Failure of metabolite clearance in a model of multi-lacunar infarctsR01NS078167 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2012 to 2016
$1.8M
The glymphatic system, a new concept in glia biologyR01NS078304 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2012 to 2016
$1.7M
ATP as the instigator of inflammatory responses to spinal cord injuryR01NS075177 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2012 to 2016
$1.6M
Cross-talk between PKA, cellular tension, and Ca2+ channels during cell migrationR01GM097495 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HOWE, ALAN K · 2011 to 2014
$1.2M
NCCIH NIH HHS R01 AT001121NCCIH NIH HHS R01-AT01121NIGMS NIH HHS R01 GM097495NINDS NIH HHS R01 NS075177NINDS NIH HHS R01 NS078167NINDS NIH HHS R01 NS078304
6 · The paper itself

Abstract

The biomechanical behavior of connective tissue in response to stretching is generally attributed to the molecular composition and organization of its extracellular matrix. It also is becoming apparent that fibroblasts play an active role in regulating connective tissue tension. In response to static stretching of the tissue, fibroblasts expand within minutes by actively remodeling their cytoskeleton. This dynamic change in fibroblast shape contributes to the drop in tissue tension that occurs during viscoelastic relaxation. We propose that this response of fibroblasts plays a role in regulating extracellular fluid flow into the tissue, and protects against swelling when the matrix is stretched. This article reviews the evidence supporting possible mechanisms underlying this response including autocrine purinergic signaling. We also discuss fibroblast regulation of connective tissue tension with respect to lymphatic flow, immune function, and cancer.

Indexed as

AnimalsConnective TissueCytoskeletonExtracellular MatrixFibroblastsHumansTensile Strength

Identifiers

PMID23444198
PMCPMC3746739
OpenAlexW1977333576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.