ArticleAmerican journal of epidemiology2013
Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women's Health Study.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- The association between telomere length and cancer risk in population studies.Scientific reports · 2016Pooled it
- DCAF4, a novel gene associated with leucocyte telomere length.Journal of medical genetics · 2015Pooled it
- Trial
- The Association Between Longer Maternal Leukocyte Telomere Length in the Immediate Postpartum Period and Preterm Birth in a Predominately Latina Cohort of Mothers.Maternal and child health journal · 2025Article
- Role of Endorphins in Breast Cancer Pathogenesis and Recovery.Advances in neurobiology · 2024Article
- Obesity-Senescence-Breast Cancer: Clinical Presentation of a Common Unfortunate Cycle.Advances in experimental medicine and biology · 2024Review
- Relationship between Telomere Length,International journal of molecular sciences · 2022Article
- Association between Physical Activity and Telomere Length in Women with Breast Cancer: A Systematic Review.Journal of clinical medicine · 2022Review
- Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study.Frontiers in oncology · 2022Article
- Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco.Environmental health : a global access science source · 2021Article
- Leukocyte telomere length, cancer incidence and all-cause mortality among Chinese adults: Singapore Chinese Health Study.International journal of cancer · 2021Article
- Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population.Molecular biology reports · 2021Article
- Impact of DAXX and ATRX expression on telomere length and prognosis of breast cancer patients.Journal of the Egyptian National Cancer Institute · 2020Article
- SNHG1 Long Noncoding RNA is Potentially Up-Regulated in Colorectal Adenocarcinoma.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors.Asian Pacific journal of cancer prevention : APJCP · 2020Review
- Association between prediagnostic leukocyte telomere length and breast cancer risk: the Singapore Chinese Health Study.Breast cancer research : BCR · 2019Article
- Shorter Telomere Length Is Associated with Increased Breast Cancer Risk in a Chinese Han Population: A Case-Control Analysis.Journal of breast cancer · 2018Article
- Chromosome Abnormalities and Absolute Telomere Lengths of Leukocytes from Silk Weavers with Emphasis on Potential Genotoxicity and Mutagenicity of Silk DyesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Telomere shortening in breast cancer cells (MCF7) under treatment with low doses of the benzylisoquinoline alkaloid chelidonine.PloS one · 2018Article
- Leucocytes telomere length and breast cancer risk/ susceptibility: A case-control study.PloS one · 2018Article
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12 authors at 1 institution in 1 country.
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Abstract
Telomeres are specialized chromatin structures essential for the maintenance of chromosomal integrity and stability. Telomere shortening has been linked to multiple aging-related diseases, including cancer. Evidence associating telomere length with breast cancer risk-most of which has been from retrospective case-control studies-is conflicting. We conducted a nested case-control study based on the Shanghai Women's Health Study (1997-2009) in which we evaluated the association of telomere length and breast cancer risk using peripheral blood samples collected before cancer diagnosis (601 cases and 695 controls). We used monochrome multiplex quantitative polymerase chain reaction to measure relative telomere length. Multiple logistic regressions were used to derive adjusted odds ratios with 95% confidence intervals as the measure of association. Telomere length was inversely correlated with age (r = -0.22). Women with moderately long telomeres (those in the fourth quintile) had the lowest breast cancer risk. Risk increased in a dose-response manner with decreasing quintile of telomere length; odds ratios were 1.39 (95% confidence interval (CI): 0.95, 2.04), 1.79 (95% CI: 1.17, 2.75), and 2.39 (95% CI: 1.45, 3.92), respectively, for the third, second, and first quintiles compared with the fourth quintile. A slightly elevated risk of breast cancer (odds ratio = 1.35, 95% CI: 0.90, 2.04), although one that was not statistically significant, was found in the top quintile (longest telomeres). Our results support the hypothesis that telomere shortening is associated with increased risk of breast cancer and suggest a possible elevated risk associated with long telomeres.
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