ArticleFrontiers in immunology2013
Chemokines in innate and adaptive granuloma formation.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Chemokine expression profile of an innate granuloma.bioRxiv : the preprint server for biology · 2024Article
- Plasma CXCL8 and MCP-1 as surrogate plasma biomarkers of latent tuberculosis infection among household contacts-A cross-sectional study.PLOS global public health · 2023Article
- Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis.Frontiers in nutrition · 2023Article
- Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles.Communications biology · 2022Review
- In the Thick of It: Formation of the Tuberculous Granuloma and Its Effects on Host and Therapeutic Responses.Frontiers in immunology · 2022Review
- Current concepts in granulomatous immune responses.Biologia futura · 2021Review
- [What is a granuloma?]Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2017Review
- Renal allograft granulomatous interstitial nephritis: observations of an uncommon injury pattern in 22 transplant recipients.Clinical kidney journal · 2017Article
- The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.Disease models & mechanisms · 2015Article
- Granulomatous response to Coxiella burnetii, the agent of Q fever: the lessons from gene expression analysis.Frontiers in cellular and infection microbiology · 2014Article
- Infections Caused by Mycobacterium tuberculosis in Recipients of Hematopoietic Stem Cell Transplantation.Frontiers in oncology · 2014Review
- New perspectives on ancient granulomas.Frontiers in immunology · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Granulomas are cellular inflammations that vary widely in histologic appearance depending upon the inciting agent and immunologic status of the responding host. Despite their heterogeneity, granulomas are at their core an ancient innate sequestration response characterized by the accumulation of mononuclear phagocytes. In fact, this innate cellular response was first observed by Metchnikov in simple invertebrates. Among higher vertebrates, environmental pressures have resulted in the evolution of more sophisticated adaptive immune responses which can be superimposed upon and modify the character of granulomatous inflammation. Compared to immune responses that rapidly neutralize and eliminate infectious agents, the granuloma represents a less desirable "fall back" response which still has value to the host but can be co-opted by certain infectious agents and contribute to bystander organ damage. Understanding granulomas requires an analysis of the complex interplay of innate and adaptive molecular signals that govern the focal accumulation and activity of their cellular components. Among these signals, small molecular weight chemoattractant proteins known as chemokines are potentially important contributors as they participate in both directing leukocyte migration and function. This tract will discuss the contribution of chemokines to the development of innate and adaptive granuloma formation, as well as describe their relationship to more recently evolved cytokines generated during adaptive immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.