ArticleFrontiers in human neuroscience2013
Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
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- The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances.Dialogues in clinical neuroscience · 2025Article
- Study on oxidative stress and inflammatory/antioxidant substance levels in autism spectrum disorder.Journal of the Chinese Medical Association : JCMA · 2023Article
- Adverse Childhood Events, Post-Traumatic Stress Disorder, Infectious Encephalopathies and Immune-Mediated Disease.Healthcare (Basel, Switzerland) · 2022Review
- Plasma acetylcholine and nicotinic acid are correlated with focused preference for photographed females in depressed males: an economic game study.Scientific reports · 2021Article
- Importance of SARs-Cov-2 anosmia: From phenomenology to neurobiology.Comprehensive psychiatry · 2020Review
- Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies.Frontiers in cellular neuroscience · 2019Article
- The brain as a "hyper-network": the key role of neural networks as main producers of the integrated brain actions especially via the "broadcasted" neuroconnectomics.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.Scientific reports · 2018Article
- Dynamic Effects of Early Adolescent Stress on Depressive-Like Behaviors and Expression of Cytokines and JMJD3 in the Prefrontal Cortex and Hippocampus of Rats.Frontiers in psychiatry · 2018Article
- Brain atrophy in the visual cortex and thalamus induced by severe stress in animal model.Scientific reports · 2017Article
- Oligodendrocyte-microglia cross-talk in the central nervous system.Immunology · 2014Review
- Editorial on psychoanalytical neuroscience: exploring psychoanalytic concepts with neuroscientific methods.Frontiers in human neuroscience · 2014Article
- Neuron-glia interaction as a possible glue to translate the mind-brain gap: a novel multi-dimensional approach toward psychology and psychiatry.Frontiers in psychiatry · 2013Review
- Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation.Mediators of inflammation · 2013Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unconscious mind-brain relationship remains unresolved. From the perspective of neuroscience, neuronal networks including synapses have been dominantly believed to play crucial roles in human mental activities, while glial contribution to mental activities has long been ignored. Recently, it has been suggested that microglia, glial cells with immunological/inflammatory functions, play important roles in psychiatric disorders. Newly revealed microglial roles, such as constant direct contact with synapses even in the normal brain, have defied the common traditional belief that microglia do not contribute to neuronal networks. Recent human neuroeconomic investigations with healthy volunteers using minocycline, an antibiotic with inhibitory effects on microglial activation, suggest that microglia may unconsciously modulate human social behaviors as "noise." We herein propose a novel unconscious mind structural system in the brain centering on microglia from a neuropsychoanalytic approach. At least to some extent, microglial activation in the brain may activate unconscious drives as "psychological immune memory/reaction" in the mind, and result in various emotions, traumatic reactions, psychiatric symptoms including suicidal behaviors, and (psychoanalytic) transference during interpersonal relationships. Microglia have the potential to bridge the huge gap between neuroscience, biological psychiatry, psychology and psychoanalysis as a key player to connect the conscious and the unconscious world.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.