ArticleAmerican journal of hypertension2013
Low-dose angiotensin II infusion restores vascular function in cerebral arteries of high salt-fed rats by increasing copper/zinc superoxide dimutase expression.
Article in American journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Controlled Feeding of an 8-d, High-Dairy Cheese Diet Prevents Sodium-Induced Endothelial Dysfunction in the Cutaneous Microcirculation of Healthy, Older Adults through Reductions in Superoxide.The Journal of nutrition · 2020Trial
- Apocynin and Tempol ameliorate dietary sodium-induced declines in cutaneous microvascular function in salt-resistant humans.American journal of physiology. Heart and circulatory physiology · 2019Trial
- Impact of High Dietary Salt on Neurovascular and Cognitive Functions.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Article
- Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet.Cardiovascular research · 2025Article
- Dietary salt, vascular dysfunction, and cognitive impairment.Cardiovascular research · 2025Review
- Article
- Salty Subjects: Unpacking Racial Differences in Salt-Sensitive Hypertension.Current hypertension reports · 2024Review
- The damaging duo: Obesity and excess dietary salt contribute to hypertension and cardiovascular disease.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- Effect of Chronically Suppressed Plasma Angiotensin II on Regulation of the CYP4A/20-HETE Pathway in the Dahl Salt-Sensitive Rat.Antioxidants (Basel, Switzerland) · 2023Article
- Oxidative Stress Induced by High Salt Diet-Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction inAntioxidants (Basel, Switzerland) · 2022Review
- Dietary sodium and health: How much is too much for those with orthostatic disorders?Autonomic neuroscience : basic & clinical · 2022Review
- Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome.Frontiers in physiology · 2022Review
- Mechanisms of Dietary Sodium-Induced Impairments in Endothelial Function and Potential Countermeasures.Nutrients · 2021Review
- A high salt meal does not impair cerebrovascular reactivity in healthy young adults.Physiological reports · 2020Article
- Enhanced Antioxidative Defense by Vitamins C and E Consumption Prevents 7-Day High-Salt Diet-Induced Microvascular Endothelial Function Impairment in Young Healthy Individuals.Journal of clinical medicine · 2020Article
- Impact of High Salt Diet on Cerebral Vascular Function and Stroke inInternational journal of molecular sciences · 2019Article
- NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction.Microcirculation (New York, N.Y. : 1994) · 2019Article
- The Influence of Dietary Salt Beyond Blood Pressure.Current hypertension reports · 2019Review
- High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression.Microcirculation (New York, N.Y. : 1994) · 2019Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis study examined the vasoprotective role of circulating angiotensin II (ANG II) levels in the cerebral circulation of high salt (HS)-fed (SS.BN-(D13hmgc41-13hmgc23)/Mcwi) (Ren1-BN) congenic rats, which carry a normally functioning renin allele from the Brown Norway (BN) rat on the Dahl salt-sensitive genetic background.
methodsRen1-BN rats were placed on an HS (4.0% NaCl) diet for 3 days. The vasodilator response to acetylcholine (ACh; 10(-10) - 10(-6) mol/L) was assessed in isolated middle cerebral arteries (MCAs), and Western blots were performed to assess the expression of the antioxidant enzymes copper (Cu)/zinc (Zn) superoxide dismutase (SOD) and manganese (Mn) SOD in cerebral resistance vessels. A separate group of HS-fed animals were infused with either a subpressor dose of ANG II (100ng/kg/min) or saline vehicle via osmotic minipump for 3 days.
resultsHS diet eliminated acetylcholine (ACh)-induced dilation in the MCAs of the congenic rats. Western blot analysis of antioxidant enzymes showed that Cu/Zn SOD and Mn SOD expression were significantly reduced in the cerebral resistance arteries of the HS-fed rats compared with control animals fed a normal salt diet. Infusion of ANG II restored the vasodilator response to ACh in the MCAs and increased Cu/Zn SOD (but not Mn SOD) expression compared with saline-infused animals.
conclusionsThese results indicate that prevention of salt-induced ANG II suppression prevents vascular dysfunction in the cerebral circulation by preventing the downregulation of Cu/Zn SOD and vascular oxidant stress that normally occurs with HS diet.
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