ArticleMetallomics : integrated biometal science2013
Advanced microscopy of star-shaped gold nanoparticles and their adsorption-uptake by macrophages.
Article in Metallomics : integrated biometal science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Nanoparticles in CNS Therapeutics: Pioneering Drug Delivery Advancements.Current pharmaceutical design · 2025Review
- Shape-dependent gold nanoparticle interactions with a model cell membrane.Biointerphases · 2022Article
- Simultaneous Noninvasive Detection and Therapy of Atherosclerosis Using HDL Coated Gold Nanorods.Diagnostics (Basel, Switzerland) · 2022Article
- Transmission Electron Microscopy as a Powerful Tool to Investigate the Interaction of Nanoparticles with Subcellular Structures.International journal of molecular sciences · 2021Review
- Modification of Aerosol Gold Nanoparticles by Nanosecond Pulsed-Periodic Laser Radiation.Nanomaterials (Basel, Switzerland) · 2021Article
- Probing the Intracellular Bio-Nano Interface in Different Cell Lines with Gold Nanostars.Nanomaterials (Basel, Switzerland) · 2021Article
- A simple one-step procedure to synthesise gold nanostars in concentrated aqueous surfactant solutions.RSC advances · 2019Article
- Plasmon Tunability of Gold Nanostars at the Tip Apexes.ACS omega · 2018Article
- Article
- Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting.Molecules (Basel, Switzerland) · 2016Review
- SERS-active Au/SiO2 clouds in powder for rapid ex vivo breast adenocarcinoma diagnosis.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Metallic nanoparticles have diverse applications in biomedicine, as diagnostics, image contrast agents, nanosensors and drug delivery systems. Anisotropic metallic nanoparticles possess potential applications in cell imaging and therapy + diagnostics (theranostics), but controlled synthesis and growth of these anisotropic or branched nanostructures has been challenging and usually require use of high concentrations of surfactants. Star-shaped gold nanoparticles were synthesized in high yield through a seed mediated route using HEPES as a precise shape-directing capping agent. Characterization was performed using advanced electron microscopy techniques including atomic resolution TEM, obtaining a detailed characterization of nanostructure and atomic arrangement. Spectroscopy techniques showed that the particles have narrow size distribution, monodispersity and high colloidal stability, with absorbance into NIR region and high efficiency for SERS applications. Gold nanostars showed to be biocompatible and efficiently adsorbed and internalized by macrophages, as revealed by advanced FE-SEM and backscattered electron imaging techniques of complete unstained uncoated cells. Additionally, low voltage STEM and X-ray microanalysis revealed the ultra-structural location and confirmed stability of nanoparticles after endocytosis with high spatial resolution.
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Registered trials
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