Trial reportJournal of exposure science & environmental epidemiology2013
Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures.
Trial report in Journal of exposure science & environmental epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05780047 (Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals), which is not on this map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals (EDCs) in Women of Child-Bearing Age and Their Partners
Who cites it
61 citing papers in PubMed, 105 citations in OpenAlex.
- Low-plastic diet and urinary levels of plastic-associated phthalates and bisphenols: the randomized controlled PERTH Trial.Nature medicine · 2026Trial
- Perinatal Environmental Health Education Intervention to Reduce Exposure to Endocrine Disruptors: The PREVED Project.International journal of environmental research and public health · 2021Trial
- Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies.Journal of exposure science & environmental epidemiology · 2025Article
- Health impacts of exposure to synthetic chemicals in food.Nature medicine · 2025Review
- Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles.Toxics · 2025Review
- Effects of Behavioral, Clinical, and Policy Interventions in Reducing Human Exposure to Bisphenols and Phthalates: A Scoping Review.Environmental health perspectives · 2024Article
- Endocrine-disrupting chemicals: Mainstream recognition of health effects and implications for the practicing internist.Journal of internal medicine · 2024Article
- Ultra-processed and fast food consumption, exposure to phthalates during pregnancy, and socioeconomic disparities in phthalate exposures.Environment international · 2024Article
- Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts.Environmental health perspectives · 2023Article
- Interventions to Reduce Exposure to Synthetic Phenols and Phthalates from Dietary Intake and Personal Care Products: a Scoping Review.Current environmental health reports · 2023Article
- Invited Perspective: Can Eating a Healthy Diet during Pregnancy Attenuate the Obesogenic Effects of Persistent Organic Pollutants?Environmental health perspectives · 2023Article
- The Pediatrician's Role in Protecting Children from Environmental Hazards.Pediatric clinics of North America · 2023Review
- Perceptions and experiences of environmental health and risks among Latina mothers in urban Los Angeles, California, USA.Environmental health : a global access science source · 2023Article
- Does Using Corsi-Rosenthal Boxes to Mitigate COVID-19 Transmission Also Reduce Indoor Air Concentrations of PFAS and Phthalates?Environmental science & technology · 2023Article
- Dietary patterns and urinary phthalate exposure among postmenopausal women of the Women's Health Initiative.Environmental research · 2023Article
- Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps.Environment international · 2022Review
- A Clinical Preventive Strategy Based on a Digital Tool to Improve Access to Endocrine Disruptors Exposure Prevention: The MEDPREVED Study.International journal of environmental research and public health · 2022Article
- Protective effects of polyphenols against endocrine disrupting chemicals.Food science and biotechnology · 2022Review
- Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Review
- Repercussions of Bisphenol A on the Physiology of Human Osteoblasts.International journal of molecular sciences · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Diet is a primary source of exposure for high-molecular-weight phthalates and bisphenol A (BPA), but little is known about the efficacy of various interventions to reduce exposures. We conducted a randomized trial with 10 families to test the efficacy of a 5-day complete dietary replacement (Arm 1; n=21) versus written recommendations to reduce phthalate and BPA exposures (Arm 2; n=19). We measured phthalate and BPA concentrations in urine samples at baseline, intervention, and post-intervention periods. We used Wilcoxon paired signed-rank tests to assess change in concentrations across time and multi-level mixed effects regression models to assess differences between Arms 1 and 2. Urinary di(2-ethylhexyl) phthalate (DEHP) metabolite concentrations increased unexpectedly from a median of 283.7 nmol/g at baseline to 7027.5 nmol/g during the intervention (P<0.0001) among Arm 1 participants, and no significant changes were observed for Arm 2 participants. We observed a statistically significant increase in total BPA concentration between baseline and intervention periods in Arm 1 but no significant changes in Arm 2. Arm 1 food ingredient testing for DEHP revealed concentrations of 21,400 ng/g in ground coriander and 673 ng/g in milk. Food contamination with DEHP led to unexpected increases in urinary phthalate concentrations in a trial intended to minimize exposure. In the absence of regulation to reduce phthalate and BPA concentrations in food production, it may be difficult to develop effective interventions that are feasible in the general population. An estimate of DEHP daily intake for children in the dietary replacement Arm was above the US Environmental Protection Agency oral reference dose and the European Food Safety Authority's tolerable daily intake, suggesting that food contamination can be a major source of DEHP exposure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.