ArticlePrimary care respiratory journal : journal of the General Practice Airways Group2013
A new approach to grading and treating COPD based on clinical phenotypes: summary of the Spanish COPD guidelines (GesEPOC).
Article in Primary care respiratory journal : journal of the General Practice Airways Group, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02119494 (POPE-Study), which is not on this map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
POPE-Study: Phenotypes Of COPD in Central and Eastern Europe Study
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- The relationship between traditional Chinese medicine constitution and indexes in chronic obstructive pulmonary disease patients: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
- Pooled it
- Clinical characteristics of the asthma-COPD overlap syndrome--a systematic review.International journal of chronic obstructive pulmonary disease · 2015Pooled it
- Putting health status guided COPD management to the test: protocol of the MARCH study.BMC pulmonary medicine · 2013Trial
- Automated Chronic Obstructive Pulmonary Disease Phenotyping and Control Assessment in Primary Care: Retrospective Multicenter Study Using the Seleida Model.JMIR medical informatics · 2025Article
- Double-edged mitophagy: balancing inflammation and resolution in lung disease.Clinical science (London, England : 1979) · 2025Review
- Phenotypes of Exacerbations in Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2025Review
- Exploring Molecular Mechanisms and Biomarkers in COPD: An Overview of Current Advancements and Perspectives.International journal of molecular sciences · 2024Review
- [Oral antibiotic treatment of exacerbation of COPD. Beyond COVID-19].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Review
- Effect of Pulmonary Rehabilitation in Patients with Asthma COPD Overlap Syndrome: A Randomized Control Trial.Oman medical journal · 2020Article
- Occupational exposures and asthma-COPD overlap in a clinical cohort of adult-onset asthma.ERJ open research · 2019Article
- Overuse of inhaled corticosteroids in COPD: five questions for withdrawal in daily practice.International journal of chronic obstructive pulmonary disease · 2018Review
- Drugs for chronic obstructive pulmonary disease.Australian prescriber · 2017Review
- Identifying possible asthma-COPD overlap syndrome in patients with a new diagnosis of COPD in primary care.NPJ primary care respiratory medicine · 2017Article
- The recent advances of phenotypes in acute exacerbations of COPD.International journal of chronic obstructive pulmonary disease · 2017Review
- A Belgian survey on the diagnosis of asthma-COPD overlap syndrome.International journal of chronic obstructive pulmonary disease · 2017Article
- POPE study: rationale and methodology of a study to phenotype patients with COPD in Central and Eastern Europe.International journal of chronic obstructive pulmonary disease · 2016Observational
- Asthma and chronic obstructive pulmonary disease overlap syndrome (ACOS): structured literature review and physician insights.Expert review of respiratory medicine · 2016Review
- Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms.Mediators of inflammation · 2016Review
- Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management.Lancet (London, England) · 2015Review
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After the development of the COPD Strategy of the National Health Service in Spain, all scientific societies, patient organisations, and central and regional governments formed a partnership to enhance care and research in COPD. At the same time, the Spanish Society of Pneumology and Thoracic Surgery (SEPAR) took the initiative to convene the various scientific societies involved in the National COPD Strategy and invited them to participate in the development of the new Spanish guidelines for COPD (Guía Española de la EPOC; GesEPOC). Probably the more innovative approach of GesEPOC is to base treatment of stable COPD on clinical phenotypes, a term which has become increasingly used in recent years to refer to the different clinical forms of COPD with different prognostic implications. The proposed phenotypes are: (A) infrequent exacerbators with either chronic bronchitis or emphysema; (B) overlap COPD-asthma; (C) frequent exacerbators with emphysema predominant; and (D) frequent exacerbators with chronic bronchitis predominant. The assessment of severity has also been updated with the incorporation of multidimensional indices. The severity of the obstruction, as measured by forced expiratory volume in 1 second, is essential but not sufficient. Multidimensional indices such as the BODE index have shown excellent prognostic value. If the 6-minute walking test is not performed routinely, its substitution by the frequency of exacerbations (BODEx index) provides similar prognostic properties. This proposal aims to achieve a more personalised management of COPD according to the clinical characteristics and multidimensional assessment of severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.