ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2013
Metabolic imaging of bilateral anterior capsulotomy in refractory obsessive compulsive disorder: an FDG PET study.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02398318 (China Refractory-Obsessive Compulsive Disorder Deep Brain Stimulation Study), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
China Refractory-Obsessive Compulsive Disorder Deep Brain Stimulation Study
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Defining functional brain networks underlying obsessive-compulsive disorder (OCD) using treatment-induced neuroimaging changes: a systematic review of the literature.Journal of neurology, neurosurgery, and psychiatry · 2021Pooled it
- The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review.BMC psychiatry · 2016Pooled it
- Neuroimaging in lesioning therapy for obsessive-compulsive disorder: region-based and network analysis of preoperative outcome predictors and postoperative effects.NeuroImage. Clinical · 2026Review
- Validity and Reliability of a Novel AI-Based System in Athletic Performance Assessment: The Case of DeepSport.Sensors (Basel, Switzerland) · 2025Article
- Clinical features, disease progression, and nuclear imaging in ATXN2-related parkinsonism in a longitudinal cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Neuroablative Intervention for Refractory Obsessive-Compulsive Disorder.Psychiatry investigation · 2023Article
- Dissecting Psychiatric Heterogeneity and Comorbidity with Core Region-Based Machine Learning.Neuroscience bulletin · 2023Review
- Brain metabolic changes and clinical response to superolateral medial forebrain bundle deep brain stimulation for treatment-resistant depression.Molecular psychiatry · 2022Article
- Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- The prefrontal cortex and neurosurgical treatment for intractable OCD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder.Journal of neurology, neurosurgery, and psychiatry · 2021Article
- Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder.The American journal of psychiatry · 2021Review
- Hypoactivity in the Paraterminal Gyrus Following Bilateral Anterior Capsulotomy.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Morphopathological changes in obsessive-compulsive disorder.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2020Article
- Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy.BMC psychiatry · 2019Article
- Preserved caudate function in young-onset patients with Parkinson's disease: a dual-tracer PET imaging study.Therapeutic advances in neurological disorders · 2019Article
- Clinical characteristics of cognitive impairment in patients with Parkinson's disease and its related pattern inHuman brain mapping · 2018Article
- Reproducible network and regional topographies of abnormal glucose metabolism associated with progressive supranuclear palsy: Multivariate and univariate analyses in American and Chinese patient cohorts.Human brain mapping · 2018Article
- Validation of abnormal glucose metabolism associated with Parkinson's disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging.Neuropsychiatric disease and treatment · 2018Article
- Effects of Anterior Capsulotomy on Decision Making in Patients with Refractory Obsessive-Compulsive Disorder.Frontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The therapeutic benefits of bilateral capsulotomy for the treatment of refractory obsessive compulsive disorder (OCD) are probably attributed to interruption of the cortico-striato-thalamo-cortical circuitry. We evaluated resting brain metabolism and treatment response in OCD patients using positron emission tomography (PET) imaging. [(18)F]-fluoro-deoxy-glucose PET was performed in eight OCD patients precapsulotomy and postcapsulotomy. We determined metabolic differences between preoperative images in patients and those in eight age-matched healthy volunteers, and postoperative changes and clinical correlations in the patients. The OCD patients showed widespread metabolic increases in normalized glucose metabolism in the bilateral orbitofrontal cortex and inferior frontal gyrus, cingulate gyrus, and bilateral pons/cerebellum, and metabolic decreases bilaterally in the precentral and lingual gyri. Bilateral capsulotomy resulted in significant metabolic decreases bilaterally in the prefrontal cortical regions, especially in the dorsal anterior cingulate cortex (ACC) and in the medial dorsal thalamus and caudate nucleus. In contrast, metabolism increased bilaterally in the precentral and lingual gyri. Clinical improvement in patients correlated with metabolic changes in the bilateral dorsal ACC and in the right middle occipital gyrus after capsulotomy. This study underscores the importance of the internal capsule in modulating ventral prefrontal and dorsal anterior cingulate neuronal activity in the neurosurgical management of OCD patients.
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Registered trials
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