ReviewInternational journal of molecular sciences2012
Brain metastases from colorectal cancer: microenvironment and molecular mechanisms.
Review in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review: brain metastases from colorectal cancer--Incidence and patient characteristics.BMC cancer · 2016Pooled it
- FOXM1 expression is induced by the brain microenvironment and supports CRC brain metastatic adaptation.Clinical & experimental metastasis · 2026Article
- Bacterial extracellular vesicles in colorectal cancer: mechanisms, biomarker potential, and therapeutic engineering.Cell communication and signaling : CCS · 2026Review
- Antitumor Activity of the Ethanolic Extract fromPharmaceutics · 2026Article
- A Challenging Case of Recurrent Cholangitis Caused by Isolated Bile Duct Metastasis of Colorectal Adenocarcinoma: Rescue Therapy through Endoscopic Ultrasound-Guided Hepaticoesophagostomy.GE Portuguese journal of gastroenterology · 2025Article
- Incidence, demographics, and survival of patients with brain metastases from stage IV colorectal cancer: a population-based study from 2013 to 2023.Journal of neuro-oncology · 2025Article
- Consensus molecular subtyping of colorectal carcinoma brain metastases reveals a metabolic signature associated with poor patient survival.Molecular oncology · 2025Article
- Survival Analysis, Clinical Characteristics, and Predictors of Cerebral Metastases in Patients with Colorectal Cancer.Medical sciences (Basel, Switzerland) · 2024Article
- A case of dMMR/MSI-H/TMB-H colon cancer with brain metastasis treated with PD-1 monoclonal antibody.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Cetuximab plus XELOX show efficacy against brain metastasis from colorectal cancer: a case report.CNS oncology · 2023Article
- Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy.Clinical & experimental metastasis · 2022Review
- Increased PPARD Expression May Play a Protective Role in Human Lung Adenocarcinoma and Squamous Cell Carcinoma.PPAR research · 2022Article
- Factors Prognostic for Brain Metastases from Colorectal Cancer: A Single-Center Experience in China.Cancer management and research · 2021Article
- Brain metastases from primary colorectal cancer: is radiosurgery an effective treatment approach? Results of a multicenter study of the radiation and clinical oncology Italian association (AIRO).The British journal of radiology · 2020Article
- Brain Metastasis as Initial Presentation of Rectal Adenocarcinoma: an Unusual Case in a Very Young Patient.Journal of gastrointestinal cancer · 2018Article
- A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models.Molecular therapy oncolytics · 2018Article
- Brain metastasis from colorectal cancer: a single center experience.Annals of surgical treatment and research · 2018Article
- Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry.Cancer biology & medicine · 2017Article
- Central nervous system metastasis secondary to colorectal cancer: a retrospective cohort study of 20 cases.Ecancermedicalscience · 2016Review
- Computational systems biology in cancer brain metastasis.Frontiers in bioscience (Scholar edition) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis associated molecules in brain metastases from colorectal cancer. A further understanding of these mechanisms will help us to propose better strategies for colorectal cancer patients with brain metastasis and improve their life quality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.