ArticleEuropean journal of human genetics : EJHG2013
HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy.
Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.Nature communications · 2015Pooled it
- HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals.The journal of allergy and clinical immunology. Global · 2025Article
- Redefining the Role of Nutrition in Infant Food Allergy Prevention: A Narrative Review.Nutrients · 2024Review
- Review
- Associations between HLA class II alleles and IgE sensitization to allergens in the Qatar Biobank cohort.The journal of allergy and clinical immunology. Global · 2023Article
- A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with atopic dermatitis.Frontiers in genetics · 2023Article
- In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps.PloS one · 2022Article
- Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring.Frontiers in immunology · 2022Review
- Genome-wide association study reveals an association between the HLA-DPB1American journal of human genetics · 2021Article
- Association between human leukocyte antigens (HLAs) and human neutrophil antigens (HNAs) and autoimmune neutropenia of infancy in Danish patients.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Article
- Advancing Food Allergy Through Omics Sciences.The journal of allergy and clinical immunology. In practice · 2021Review
- Current insights into the genetics of food allergy.The Journal of allergy and clinical immunology · 2021Review
- Association of HLA-DQ and IL13 gene variants with challenge-proven shrimp allergy in West Bengal, India.Immunogenetics · 2020Article
- HLA Polymorphisms and Food Allergy Predisposition.Journal of pediatric genetics · 2020Review
- IgE-Mediated Peanut Allergy: Current and Novel Predictive Biomarkers for Clinical Phenotypes Using Multi-Omics Approaches.Frontiers in immunology · 2020Review
- Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy.Medicine · 2018Observational
- Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region.Scientific reports · 2018Article
- Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.Nature communications · 2017Article
- Multifactorial Modulation of Food-Induced Anaphylaxis.Frontiers in immunology · 2017Review
- Are genetic tests informative in predicting food allergy?Current opinion in allergy and clinical immunology · 2016Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
Peanut allergy (PA) is a common and serious food allergy and its prevalence has increased in the past decade. Although there is strong evidence of inheritance, the genetic causes of this disease are not well understood. Previously, a large-scale genome-wide association study described an association between human leukocyte antigen (HLA)-DQB1 and asthma; the aim of this study was to evaluate the association between HLA-DQB1 and PA. Genotypic and allelic profiles were established for 311 Caucasian members of a well-described Canadian group of children with PA and 226 Caucasian controls. Firth's logistic regression analyses showed associations between HLA-DQB1 alleles and PA for DQB1*02 (P=1.1 × 10(-8), odds ratio (OR)=0.09 (CI=0.03-0.23)) and DQB1*06:03P alleles (P=2.1 × 10(-2), OR=2.82 (CI=1.48-5.45)). This study of HLA in PA demonstrates specific association between two allelic groups of the HLA-DQB1 gene (DQB1*02 and DQB1*06:03P) and PA, highlighting its possible role in the development of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.