ArticleBiophysical journal2013
Wide-angle X-ray solution scattering for protein-ligand binding: multivariate curve resolution with Bayesian confidence intervals.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Article
- Enzyme kinetics model for the coronavirus main protease including dimerization and ligand binding.Biophysical journal · 2025Article
- Quantifying cooperative multisite binding in the hub protein LC8 through Bayesian inference.PLoS computational biology · 2023Article
- Bayesian regression and model selection for isothermal titration calorimetry with enantiomeric mixtures.PloS one · 2022Article
- Article
- Article
- A simple adaptation to a protein crystallography station to facilitate difference X-ray scattering studies.Journal of applied crystallography · 2019Article
- Article
- Understanding nucleic acid structural changes by comparing wide-angle x-ray scattering (WAXS) experiments to molecular dynamics simulations.The Journal of chemical physics · 2016Article
- Constrained Maximum Likelihood Estimation of Relative Abundances of Protein Conformation in a Heterogeneous Mixture from Small Angle X-Ray Scattering Intensity Measurements.IEEE transactions on signal processing : a publication of the IEEE Signal Processing Society · 2015Article
- Investigating increasingly complex macromolecular systems with small-angle X-ray scattering.IUCrJ · 2014Review
- Singular value decomposition as a tool for background corrections in time-resolved XFEL scattering data.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- The structure of the catalytic domain of a plant cellulose synthase and its assembly into dimers.The Plant cell · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
A new way to use wide-angle x-ray solution scattering to study protein-ligand binding is presented. First, scattering patterns are measured at different protein and ligand concentrations. Multivariate curve resolution based on singular value decomposition and global analysis is applied to estimate the binding affinities and reference patterns (i.e., the scattering patterns of individual components). As validated by simulation, Bayesian confidence intervals provide accurate uncertainty estimates for the binding free energies and reference patterns. Experimental results from several protein-ligand systems demonstrate the feasibility of the approach, which promises to expand the role of wide-angle x-ray scattering as a quantitative biophysical tool.
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Registered trials
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