ArticleBiophysical journal2013
Highly abundant proteins favor more stable 3D structures in yeast.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Amino acid sequence encodes protein abundance shaped by protein stability at reduced synthesis cost.Protein science : a publication of the Protein Society · 2025Article
- Highly Abundant Proteins Are Highly Thermostable.Genome biology and evolution · 2023Article
- Atomistic simulation of protein evolution reveals sequence covariation and time-dependent fluctuations of site-specific substitution rates.PLoS computational biology · 2023Article
- Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability.Nature ecology & evolution · 2022Article
- Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins.Frontiers in molecular biosciences · 2021Article
- How Do Cells Adapt? Stories Told in Landscapes.Annual review of chemical and biomolecular engineering · 2020Review
- Protein Melting Temperature Cannot Fully Assess Whether Protein Folding Free Energy Underlies the Universal Abundance-Evolutionary Rate Correlation Seen in Proteins.Molecular biology and evolution · 2019Article
- Article
- Central dogma rates and the trade-off between precision and economy in gene expression.Nature communications · 2019Article
- Evolution on the Biophysical Fitness Landscape of an RNA Virus.Molecular biology and evolution · 2018Article
- Protein evolution speed depends on its stability and abundance and on chaperone concentrations.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Biophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence.Annual review of biophysics · 2017Review
- Optimization of lag phase shapes the evolution of a bacterial enzyme.Nature ecology & evolution · 2017Article
- The Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.Biophysical journal · 2017Article
- Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.Current opinion in structural biology · 2017Review
- On the origin of protein superfamilies and superfolds.Scientific reports · 2015Article
- The influence of selection for protein stability on dN/dS estimations.Genome biology and evolution · 2014Article
- Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics.Current opinion in structural biology · 2014Review
- A model of proteostatic energy cost and its use in analysis of proteome trends and sequence evolution.PloS one · 2014Article
- Proteome folding kinetics is limited by protein halflife.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
To understand the variation of protein sequences in nature, we need to reckon with evolutionary constraints that are biophysical, cellular, and ecological. Here, we show that under the global selection against protein misfolding, there exists a scaling among protein folding stability, protein cellular abundance, and effective population size. The specific scaling implies that the several-orders-of-magnitude range of protein abundances in the cell should leave imprints on extant protein structures, a prediction that is supported by our structural analysis of the yeast proteome.
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Registered trials
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