ArticleBiophysical journal2013
Physical constraints on biological integral control design for homeostasis and sensory adaptation.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed.
- Automated Classification of Homeostasis Structure in Input-Output Networks.Bulletin of mathematical biology · 2026Article
- The Duality of Astrocyte Neuromodulation: Astrocytes Sense Neuromodulators and Are Neuromodulators.Journal of neurochemistry · 2025Review
- Homeostasis in networks with multiple inputs.Journal of mathematical biology · 2024Article
- Background compensation revisited: Conserved phase response curves in frequency controlled homeostats with coherent feedback.PloS one · 2024Article
- Noise properties of adaptation-conferring biochemical control modules.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Self-complexification through integral feedback in eusocial paper wasps of various levels of sociality.Heliyon · 2023Article
- Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation.PloS one · 2023Article
- Coherent feedback leads to robust background compensation in oscillatory and non-oscillatory homeostats.PloS one · 2023Article
- Protein-protein complexes can undermine ultrasensitivity-dependent biological adaptation.Journal of the Royal Society, Interface · 2023Article
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- Frequency-preference response in covalent modification cycles under substrate sequestration conditions.NPJ systems biology and applications · 2021Article
- The structure of infinitesimal homeostasis in input-output networks.Journal of mathematical biology · 2021Article
- An amplified derepression controller with multisite inhibition and positive feedback.PloS one · 2021Article
- Infinitesimal homeostasis in three-node input-output networks.Journal of mathematical biology · 2020Article
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- Adaptive information processing of network modules to dynamic and spatial stimuli.BMC systems biology · 2019Article
- Integral feedback control is at the core of task allocation and resilience of insect societies.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A quasi-integral controller for adaptation of genetic modules to variable ribosome demand.Nature communications · 2018Article
- Realizing 'integral control' in living cells: how to overcome leaky integration due to dilution?Journal of the Royal Society, Interface · 2018Article
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2 authors.
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Abstract
Synthetic biology includes an effort to use design-based approaches to create novel controllers, biological systems aimed at regulating the output of other biological processes. The design of such controllers can be guided by results from control theory, including the strategy of integral feedback control, which is central to regulation, sensory adaptation, and long-term robustness. Realization of integral control in a synthetic network is an attractive prospect, but the nature of biochemical networks can make the implementation of even basic control structures challenging. Here we present a study of the general challenges and important constraints that will arise in efforts to engineer biological integral feedback controllers or to analyze existing natural systems. Constraints arise from the need to identify target output values that the combined process-plus-controller system can reach, and to ensure that the controller implements a good approximation of integral feedback control. These constraints depend on mild assumptions about the shape of input-output relationships in the biological components, and thus will apply to a variety of biochemical systems. We summarize our results as a set of variable constraints intended to provide guidance for the design or analysis of a working biological integral feedback controller.
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