ArticleGenome biology2013
The BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila.
Article in Genome biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
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- Tissue-specific RNA Polymerase II promoter-proximal pause release and burst kinetics in a Drosophila embryonic patterning network.Genome biology · 2024Article
- Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription.Nature communications · 2023Article
- RNA Polymerase II "Pause" Prepares Promoters for Upcoming Transcription duringInternational journal of molecular sciences · 2022Article
- The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival.Chromosoma · 2021Article
- Kinome-Wide RNAi Screen Uncovers Role of Ballchen in Maintenance of Gene Activation by Trithorax Group inFrontiers in cell and developmental biology · 2021Article
- Interplay Between BALL and CREB Binding Protein Maintains H3K27 Acetylation on Active Genes inFrontiers in cell and developmental biology · 2021Article
- Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming.Annual review of biochemistry · 2020Review
- Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation.Nature communications · 2020Article
- Article
- Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent.Nature communications · 2019Article
- Digital expression explorer 2: a repository of uniformly processed RNA sequencing data.GigaScience · 2019Article
- The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression.Nature communications · 2018Article
- Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC.Development (Cambridge, England) · 2018Article
- Pho dynamically interacts with Spt5 to facilitate transcriptional switches at the hsp70 locus.Epigenetics & chromatin · 2017Article
- Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.Nature communications · 2017Article
- Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes inGenes & development · 2017Article
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.PLoS genetics · 2016Article
- Integrative omics analysis. A study based on Plasmodium falciparum mRNA and protein data.BMC systems biology · 2014Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe question of how cells re-establish gene expression states after cell division is still poorly understood. Genetic and molecular analyses have indicated that Trithorax group (TrxG) proteins are critical for the long-term maintenance of active gene expression states in many organisms. A generally accepted model suggests that TrxG proteins contribute to maintenance of transcription by protecting genes from inappropriate Polycomb group (PcG)-mediated silencing, instead of directly promoting transcription. RESULTS AND DISCUSSION: Here we report a physical and functional interaction in Drosophila between two members of the TrxG, the histone methyltransferase ASH1 and the bromodomain and extraterminal family protein FSH. We investigated this interface at the genome level, uncovering a widespread co-localization of both proteins at promoters and PcG-bound intergenic elements. Our integrative analysis of chromatin maps and gene expression profiles revealed that the observed ASH1-FSH binding pattern at promoters is a hallmark of active genes. Inhibition of FSH-binding to chromatin resulted in global down-regulation of transcription. In addition, we found that genes displaying marks of robust PcG-mediated repression also have ASH1 and FSH bound to their promoters.
conclusionsOur data strongly favor a global coactivator function of ASH1 and FSH during transcription, as opposed to the notion that TrxG proteins impede inappropriate PcG-mediated silencing, but are dispensable elsewhere. Instead, our results suggest that PcG repression needs to overcome the transcription-promoting function of ASH1 and FSH in order to silence genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.