Evidence map›Paper›PMID 23442307›Full record

ArticleThe oncologist2013

The financial toxicity of cancer treatment: a pilot study assessing out-of-pocket expenses and the insured cancer patient's experience.

S Yousuf Zafar, Jeffrey M Peppercorn, Deborah Schrag, Donald H Taylor, Amy M Goetzinger, Xiaoyin Zhong, Amy P Abernethy

4 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in The oncologist, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 588 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
588citing papers in PubMed, 10 pooled it
189.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03422198 phase3recruitingnot on this mapstarted 2018, after this paper: background citation

Short Course Adjuvant Vaginal Cuff Brachytherapy (VCB) in Early Endometrial Cancer Compared to Standard of Care (SAVE)

TypeinterventionalSponsorUniversity of UtahRan2018 to 2029Enrolled188ConditionsEndometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Serous Adenocarcinoma, Stage I Uterine Corpus CancerArmsVaginal Cuff Brachytherapy, Short course vaginal cuff brachytherapy
NCT06072833 nacompletednot on this mapstarted 2023, after this paper: background citation

Characterizing and Addressing Financial Toxicity in Adolescents and Young Adults With Cancer

TypeinterventionalSponsorColumbia UniversityRan2023 to 2025Enrolled26ConditionsCancer in AdolescenceArmsPatient Financial Education / Navigation
NCT06278831 completednot on this mapstarted 2023, after this paper: background citation

Efficacy of Structured SOcial COnsultation and Support in Reducing the FINancial Burden of Radiotherapy

TypeobservationalSponsorUniversity Medical Center GoettingenRan2023 to 2024Enrolled230ConditionsFinancial ToxicityArmsQuestionnaire
NCT06296641 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Leveraging COmmunity Partnered nEeds Navigation to Reduce Unmet Health-related Social Needs Among Caregivers for Adolescent and Younger Adult Cancer Survivors

TypeinterventionalSponsorColumbia UniversityRan2024 to 2026Enrolled60ConditionsCancer in AdolescenceArmsNeeds navigation intervention
3 · Its place in the literature

Who cites it

588 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,082 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Towards the assessment of financial distress among cancer patients: a conceptual model of the financial effects of a tumour disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Measuring financial toxicity in head and neck cancer: a systematic review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Guideline
  11. Trial
  12. Financial hardship experience in middle- and older-aged patients with advanced lung cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  13. Review
  14. Inequities in enrollment across clinical trial phases and the need for a Spanish perspective.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  15. Assessing financial toxicity with COST-FACIT: experience from a tertiary care cancer center.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Beyond tumor response: hope and decision regret during immunotherapy for hepatocellular carcinoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  20. Article

528 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

S Yousuf ZafarCenter for Learning Health Care, Duke Clinical Research Institute, Duke Cancer Institute, Durham, North Carolina 27710, USA. yousuf.zafar@duke.edu
Jeffrey M Peppercorn
Deborah Schrag
Donald H Taylor
Amy M Goetzinger
Xiaoyin Zhong
Amy P Abernethy
Durham University · GBClinical Research Institute · USDana-Farber Cancer Institute · USDuke Medical Center · USDuke University · USUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer patients carry rising burdens of health care-related out-of-pocket expenses, and a growing number of patients are considered "underinsured." Our objective was to describe experiences of insured cancer patients requesting copayment assistance and to describe the impact of health care expenses on well-being and treatment.

methodsWe conducted baseline and follow-up surveys regarding the impact of health care costs on well-being and treatment among cancer patients who contacted a national copayment assistance foundation along with a comparison sample of patients treated at an academic medical center.

resultsAmong 254 participants, 75% applied for drug copayment assistance. Forty-two percent of participants reported a significant or catastrophic subjective financial burden; 68% cut back on leisure activities, 46% reduced spending on food and clothing, and 46% used savings to defray out-of-pocket expenses. To save money, 20% took less than the prescribed amount of medication, 19% partially filled prescriptions, and 24% avoided filling prescriptions altogether. Copayment assistance applicants were more likely than nonapplicants to employ at least one of these strategies to defray costs (98% vs. 78%). In an adjusted analysis, younger age, larger household size, applying for copayment assistance, and communicating with physicians about costs were associated with greater subjective financial burden.

conclusionInsured patients undergoing cancer treatment and seeking copayment assistance experience considerable subjective financial burden, and they may alter their care to defray out-of-pocket expenses. Health insurance does not eliminate financial distress or health disparities among cancer patients. Future research should investigate coverage thresholds that minimize adverse financial outcomes and identify cancer patients at greatest risk for financial toxicity.

Indexed as

Cost-Benefit AnalysisPatientsAdultAgedAged, 80 and overData CollectionFemaleFinancial SupportFollow-Up StudiesHumansMaleMiddle AgedNeoplasmsPilot ProjectsQuality of Health Care

Identifiers

PMID23442307
PMCPMC3639525
OpenAlexW2099354636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.