ArticlePhotochemistry and photobiology
PDT dose parameters impact tumoricidal durability and cell death pathways in a 3D ovarian cancer model.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Development and characterization of a combined fluorescence and spatial frequency domain imaging system for real-time dosimetry of photodynamic therapy.Journal of biomedical optics · 2025Article
- Photodynamic inactivation of bacterial biofilms on absorbable collagen membranes using indocyanine green in aqueous and hydrogen peroxide solutions.Lasers in medical science · 2025Article
- Apoptosis-inducing photodynamic therapy via dual-wavelength responsive ICG/Ce6 incorporated mesoporous silica nanoparticles in prostate cancer cells.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Photodynamic Priming Overcomes Per- and Polyfluoroalkyl Substance (PFAS)-Induced Platinum Resistance in Ovarian CancerPhotochemistry and photobiology · 2023Article
- Photosensitized co-generation of nitric oxide and singlet oxygen Enhanced toxicity against ovarian cancer cells.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2022Article
- Subcutaneous Xenograft Models for Studying PDT In Vivo.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Analysis of Treatment Effects on Structurally Complex Microtumor Cultures Using a Comprehensive Image Analysis Procedure.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Photoinduced DNA Cleavage and Photocytotoxic of Phenanthroline-Based Ligand Ruthenium Compounds.Molecules (Basel, Switzerland) · 2021Article
- Near-infrared absorbing Ru(ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma.Chemical science · 2020Article
- Blood Flow Measurements Enable Optimization of Light Delivery for Personalized Photodynamic Therapy.Cancers · 2020Article
- Light Fluence Rate and Tissue Oxygenation (SPhotochemistry and photobiology · 2020Article
- Article
- The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons.Scientific reports · 2019Article
- Impacting Pancreatic Cancer Therapy in HeterotypicNano letters · 2019Article
- Nanolipid Formulations of Benzoporphyrin Derivative: Exploring the Dependence of Nanoconstruct Photophysics and Photochemistry on Their Therapeutic Index in Ovarian Cancer Cells.Photochemistry and photobiology · 2019Article
- A Combination of Visudyne and a Lipid-anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer.Photochemistry and photobiology · 2019Article
- Erythrocyte-Derived Theranostic Nanoplatforms for Near Infrared Fluorescence Imaging and Photodestruction of Tumors.ACS applied materials & interfaces · 2018Article
- Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids.Oncotarget · 2018Article
- A Comparison of Dose Metrics to Predict Local Tumor Control for Photofrin-mediated Photodynamic Therapy.Photochemistry and photobiology · 2017Article
- Photodynamic therapy monitoring with optical coherence angiography.Scientific reports · 2017Article
Corrections and comments
- Erratum issuedCelli, Jonathan P [corrected to Celli, Jonathan]
Authors and funding
10 authors.
Funding
Abstract
The successful implementation of photodynamic therapy (PDT)-based regimens depends on an improved understanding of the dosimetric and biological factors that govern therapeutic variability. Here, the kinetics of tumor destruction and regrowth are characterized by systematically varying benzoporphyrin derivative (BPD)-light combinations to achieve fixed PDT doses (M × J cm(-2)). Three endpoints were used to evaluate treatment response: (1) Viability evaluated every 24 h for 5 days post-PDT; (2) Photobleaching assessed immediately post-PDT; and (3) Caspase-3 activation determined 24 h post-PDT. The specific BPD-light parameters used to construct a given PDT dose significantly impact not only acute cytotoxic efficacy, but also treatment durability. For each dose, PDT with 0.25 μM BPD produces the most significant and sustained reduction in normalized viability compared to 1 and 10 μM BPD. Percent photobleaching correlates with normalized viability for a range of PDT doses achieved within BPD concentrations. To produce a cytotoxic response with 10 μM BPD that is comparable to 0.25 and 1 μM BPD a reduction in irradiance from 150 to 0.5 mW cm(-2) is required. Activated caspase-3 does not correlate with normalized viability. The parameter-dependent durability of outcomes within fixed PDT doses provides opportunities for treatment customization and improved therapeutic planning.
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