ArticleBMC genomics2013
Massive screening of copy number population-scale variation in Bos taurus genome.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Long read and preliminary pangenome analyses reveal breed-specific structural variations and novel sequences in Holstein and Jersey cattle.Journal of advanced research · 2026Article
- Exploring cattle structural variation in the era of long reads, pangenome graphs, and near-complete assemblies.Journal of animal science and biotechnology · 2025Review
- Global Pangenome Analysis Highlights the Critical Role of Structural Variants in Cattle Improvement and Identifies a Unique Event as a Novel Enhancer in IGFBP7+ Cells.Molecular biology and evolution · 2025Article
- Genome-Wide Detection of Copy Number Variations Associated with Miniature Features in Horses.Genes · 2023Article
- Copy number variation of EIF4A2 loci related to phenotypic traits in Chinese cattle.Veterinary medicine and science · 2022Article
- Article
- Landscape of copy number variations in Bos taurus: individual - and inter-breed variability.BMC genomics · 2018Article
- Genetic Diversity of Seven Cattle Breeds Inferred Using Copy Number Variations.Frontiers in genetics · 2018Article
- Genome-Wide SNP Signal Intensity Scanning Revealed Genes Differentiating Cows with Ovarian Pathologies from Healthy Cows.Sensors (Basel, Switzerland) · 2017Article
- Association study and expression analysis of CYP4A11 gene copy number variation in Chinese cattle.Scientific reports · 2017Article
- In vivo and in vitro ageing results in accumulation of de novo copy number variations in bulls.Scientific reports · 2017Article
- Genome-wide copy number variation (CNV) detection in Nelore cattle reveals highly frequent variants in genome regions harboring QTLs affecting production traits.BMC genomics · 2016Article
- Copy number variants in the sheep genome detected using multiple approaches.BMC genomics · 2016Article
- Diversity and population-genetic properties of copy number variations and multicopy genes in cattle.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Genome-wide CNV analysis reveals variants associated with growth traits in Bos indicus.BMC genomics · 2016Article
- Population-genetic properties of differentiated copy number variations in cattle.Scientific reports · 2016Article
- Genome-wide identification of copy number variation using high-density single-nucleotide polymorphism array in Japanese Black cattle.BMC genetics · 2016Article
- Genome-Wide Detection of CNVs and Their Association with Meat Tenderness in Nelore Cattle.PloS one · 2016Article
- Identification of copy number variations in Qinchuan cattle using BovineHD Genotyping Beadchip array.Molecular genetics and genomics : MGG · 2015Article
- Genome-Wide Study of Structural Variants in Bovine Holstein, Montbéliarde and Normande Dairy Breeds.PloS one · 2015Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCopy number variations (CNVs) represent a significant source of genomic structural variation. Their length ranges from approximately one hundred to millions of base pair. Genome-wide screenings have clarified that CNVs are a ubiquitous phenomenon affecting essentially the whole genome. Although Bos taurus is one of the most important domestic animal species worldwide and one of the most studied ruminant models for metabolism, reproduction, and disease, relatively few studies have investigated CNVs in cattle and little is known about how CNVs contribute to normal phenotypic variation and to disease susceptibility in this species, compared to humans and other model organisms.
resultsHere we characterize and compare CNV profiles in 2654 animals from five dairy and beef Bos taurus breeds, using the Illumina BovineSNP50 genotyping array (54001 SNP probes). In this study we applied the two most commonly used algorithms for CNV discovery (QuantiSNP and PennCNV) and identified 4830 unique candidate CNVs belonging to 326 regions. These regions overlap with 5789 known genes, 76.7% of which are significantly co-localized with segmental duplications (SD).
conclusionsThis large scale screening significantly contributes to the enrichment of the Bos taurus CNV map, demonstrates the ubiquity, great diversity and complexity of this type of genomic variation and sets the basis for testing the influence of CNVs on Bos taurus complex functional and production traits.
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