ArticleAlcoholism, clinical and experimental research2013
The association between prenatal alcohol exposure and behavior at 22 years of age.
Article in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Effects of prenatal alcohol exposure on cognitive and behavioral development: Findings from a hierarchical meta-analysis of data from six prospective longitudinal U.S. cohorts.Alcoholism, clinical and experimental research · 2021Pooled it
- Oral and written communication skills of adolescents with prenatal alcohol exposure (PAE) compared with those with no/low PAE: A systematic review.International journal of language & communication disorders · 2021Pooled it
- Prenatal alcohol exposure and offspring mental health: A systematic review.Drug and alcohol dependence · 2019Pooled it
- Sensitive periods for prenatal alcohol exposure shape internalizing symptoms across development.medRxiv : the preprint server for health sciences · 2026Article
- From teratogens to trajectories: Integrating teratology and Developmental Origins of Health and Disease (DOHaD) frameworks for a new take on fetal alcohol spectrum disorders (FASD).Neurobiology of stress · 2026Article
- Persistent Alterations of Brain and Behavior in Children With Low Prenatal Alcohol Exposure.Biological psychiatry global open science · 2026Article
- Clinical Features of Typically Developing Children with and without Prenatal Alcohol Exposure.The Journal of pediatrics · 2025Article
- Article
- Functional connectivity of cognition-related brain networks in adults with fetal alcohol syndrome.BMC medicine · 2023Article
- Moderate prenatal alcohol exposure produces sex-specific social impairments and attenuates prelimbic excitability and amygdala-cortex modulation of adult social behaviour.Addiction biology · 2023Article
- Dose-Related Reduction in Hippocampal Neuronal Populations in Fetal Alcohol Exposed Vervet Monkeys.Brain sciences · 2022Article
- Self-reported alcohol consumption of pregnant women and their partners correlates both before and during pregnancy: A cohort study with 21,472 singleton pregnancies.Alcoholism, clinical and experimental research · 2022Article
- Evaluation of Brain Alterations and Behavior in Children With Low Levels of Prenatal Alcohol Exposure.JAMA network open · 2022Article
- Maternal trajectories of cannabis use and young adult cannabis and nicotine dependence.Addictive behaviors · 2022Article
- Sex-specific effect of prenatal alcohol exposure on N-methyl-D-aspartate receptor function in orbitofrontal cortex pyramidal neurons of mice.Alcoholism, clinical and experimental research · 2021Article
- Moderate prenatal ethanol exposure leads to attention deficits in both male and female rats.Alcoholism, clinical and experimental research · 2021Article
- Prenatal risk factors for internalizing and externalizing problems in childhood.World journal of pediatrics : WJP · 2020Review
- Characterizing Alcohol-Related Neurodevelopmental Disorder: Prenatal Alcohol Exposure and the Spectrum of Outcomes.Alcoholism, clinical and experimental research · 2020Article
- Association of Prenatal Alcohol Exposure and Offspring Depression: A Negative Control Analysis of Maternal and Partner Consumption.Alcoholism, clinical and experimental research · 2020Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundPrenatal alcohol exposure (PAE) affects central nervous system development, growth, and morphology at higher exposure levels. Little is known about the effects of PAE at lower exposure levels or in young adults. Research on children with higher levels of PAE has shown that PAE predicts behavior problems. The question remains whether these effects are permanent or ameliorated by maturation into adulthood.
methodsThese data are from a longitudinal study of PAE. Mothers were recruited from a prenatal clinic and interviewed during their fourth prenatal month, seventh month, and delivery. In the postpartum, mothers and offspring were seen at 8 and 18 months, and 3, 6, 10, 14, 16, and 22 years.
resultsAt 22 years, PAE significantly predicted behavior as measured with the adult self-report. These findings were significant controlling for covariates. Exposure at each trimester predicted increased behavior problems on the Total Score, Internalizing, Externalizing, Attention, and Critical Items scales. Use across pregnancy predicted a higher rate of behavior problems compared to no use and use in the first trimester only.
conclusionsThe effects were dose-response and significant at each trimester of pregnancy. However, duration across pregnancy was a better predictor than drinking during the first trimester only. Binge drinking was not a better predictor of outcome compared to average daily volume (ADV), and within categories of ADV, binge drinking did not predict more problems than nonbinge drinking. Thus, there is no safe level or safe time during pregnancy for women to drink. These data demonstrate that the effects of PAE, even at low to moderate levels, extend into young adulthood and are most likely permanent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.