ReviewMicrocirculation (New York, N.Y. : 1994)2013
Bang-bang model for regulation of local blood flow.
Review in Microcirculation (New York, N.Y. : 1994), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- KMicrovascular research · 2025Article
- Development of thin-film micro-outlets for spatially constraining local POFrontiers in physiology · 2025Article
- Dynamics of POFrontiers in physiology · 2023Article
- Capillary-Mitochondrial Oxygen Transport in Muscle: Paradigm Shifts.Function (Oxford, England) · 2023Review
- Muscle Oxygenation Level Might Trigger the Regulation of Capillary Venous Blood Filling during Fatiguing Isometric Muscle Actions.Diagnostics (Basel, Switzerland) · 2021Article
- Localized Oxygen Exchange Platform for Intravital Video Microscopy Investigations of Microvascular Oxygen Regulation.Frontiers in physiology · 2021Article
- Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Hyper-Oxygenation Attenuates the Rapid Vasodilatory Response to Muscle Contraction and Compression.Frontiers in physiology · 2018Article
- Structural Control of Microvessel Diameters: Origins of Metabolic Signals.Frontiers in physiology · 2017Article
- Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action?The Journal of physiology · 2016Review
- The role of perfusion in the oxygen extraction capability of skin and skeletal muscle.American journal of physiology. Heart and circulatory physiology · 2016Article
- Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Skeletal muscle vasodilation during systemic hypoxia in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.Physiological reviews · 2015Review
- Muscle blood flow, hypoxia, and hypoperfusion.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- A paradigm shift for local blood flow regulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Muscle contraction increases interstitial nitric oxide as predicted by a new model of local blood flow regulation.The Journal of physiology · 2014Article
- Functional sympatholysis and sympathetic escape in a theoretical model for blood flow regulation.Frontiers in physiology · 2014Article
- Skeletal muscle capillary function: contemporary observations and novel hypotheses.Experimental physiology · 2013Review
- Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials.The international journal of biochemistry & cell biology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The classical model of metabolic regulation of blood flow in muscle tissue implies the maintenance of basal tone in arterioles of resting muscle and their dilation in response to exercise and/or tissue hypoxia via the evoked production of vasodilator metabolites by myocytes. A century-long effort to identify specific metabolites responsible for explaining active and reactive hyperemia has not been successful. Furthermore, the metabolic theory is not compatible with new knowledge on the role of physiological radicals (e.g., nitric oxide, NO, and superoxide anion, O2 (-) ) in the regulation of microvascular tone. We propose a model of regulation in which muscle contraction and active hyperemia are considered the physiologically normal state. We employ the "bang-bang" or "on/off" regulatory model which makes use of a threshold and hysteresis; a float valve to control the water level in a tank is a common example of this type of regulation. Active bang-bang regulation comes into effect when the supply of oxygen and glucose exceeds the demand, leading to activation of membrane NADPH oxidase, release of O2 (-) into the interstitial space and subsequent neutralization of the interstitial NO. Switching arterioles on/off when local blood flow crosses the threshold is realized by a local cell circuit with the properties of a bang-bang controller, determined by its threshold, hysteresis, and dead-band. This model provides a clear and unambiguous interpretation of the mechanism to balance tissue demand with a sufficient supply of nutrients and oxygen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.