ArticleJournal of neurotrauma2013
Aquaporin-4 expression in post-traumatic syringomyelia.
Article in Journal of neurotrauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia.Fluids and barriers of the CNS · 2025Article
- Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model.Fluids and barriers of the CNS · 2024Article
- The Physiological Occlusion of the Central Canal May Be a Prerequisite for Syringomyelia Formation.Neurospine · 2023Article
- Article
- Fecal microbiota transplantation alleviates experimental colitis through the Toll-like receptor 4 signaling pathway.World journal of gastroenterology · 2023Article
- Aquaporin-4 expression and modulation in a rat model of post-traumatic syringomyelia.Scientific reports · 2023Article
- Osmotic Contribution of Synthesized Betaine by Choline Dehydrogenase UsingCellular and molecular bioengineering · 2023Article
- Cerebrospinal Fluid Hydrodynamics in Chiari I Malformation and Syringomyelia: Modeling Pathophysiology.Neurosurgery clinics of North America · 2023Review
- A Brief Overview of the Cerebrospinal Fluid System and Its Implications for Brain and Spinal Cord Diseases.Frontiers in human neuroscience · 2021Review
- The Role of Astrogliosis in Formation of the Syrinx in Spinal Cord Injury.Current neuropharmacology · 2021Review
- The Pathogenesis of Neurotrauma Indicates Targets for Neuroprotective Therapies.Current neuropharmacology · 2021Article
- Imaging of Neurotrauma in Acute and Chronic Settings.Current neuropharmacology · 2021Review
- Reactive Astrocytes in Central Nervous System Injury: Subgroup and Potential Therapy.Frontiers in cellular neuroscience · 2021Review
- Detection of locomotion deficit in a post-traumatic syringomyelia rat model using automated gait analysis technique.PloS one · 2021Article
- Chronic extradural compression of spinal cord leads to syringomyelia in rat model.Fluids and barriers of the CNS · 2020Article
- Effect of extradural constriction on CSF flow in rat spinal cord.Fluids and barriers of the CNS · 2019Article
- Article
- Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner.Journal of neuroinflammation · 2017Article
- Aquaporins in the Spinal Cord.International journal of molecular sciences · 2016Review
- Melatonin lowers edema after spinal cord injury.Neural regeneration research · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquaporin-4 (AQP4) is an astroglial water channel protein that plays an important role in the transmembrane movement of water within the central nervous system. AQP4 has been implicated in numerous pathological conditions involving abnormal fluid accumulation, including spinal cord edema following traumatic injury. AQP4 has not been studied in post-traumatic syringomyelia, a condition that cannot be completely explained by current theories of cerebrospinal fluid dynamics. Alterations of AQP4 expression or function may contribute to the fluid imbalance leading to syrinx formation or enlargement. The aim of this study was to examine AQP4 expression levels and distribution in an animal model of post-traumatic syringomyelia. Immunofluorescence and western blotting were used to assess AQP4 and glial fibrillary acidic protein (GFAP) expression in an excitotoxic amino acid/arachnoiditis model of post-traumatic syringomyelia in Sprague-Dawley rats. At all time-points, GFAP-positive astrocytes were observed in tissue surrounding syrinx cavities, although western blot analysis demonstrated an overall decrease in GFAP expression, except at the latest stage investigated. AQP4 expression was significantly higher at the level of syrinx at three and six weeks following the initial syrinx induction surgery. Significant increases in AQP4 expression also were observed in the upper cervical cord, rostral to the syrinx except in the acute stage of the condition at the three-day time-point. Immunostaining showed that AQP4 was expressed around all syrinx cavities, most notably adjacent to a mature syrinx (six- and 12-week time-point). This suggests a relationship between AQP4 and fluid accumulation in post-traumatic syringomyelia. However, whether this is a causal relationship or occurs in response to an increase in fluid needs to be established.
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