ArticleInternational journal of experimental pathology2013
Experimental respiratory Marburg virus haemorrhagic fever infection in the common marmoset (Callithrix jacchus).
Article in International journal of experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- African swine fever virus: Virology, pathogenesis, clinical impact, and global control strategies.Veterinary world · 2025Review
- Evaluation of Vaccines and Therapeutics Against Marburg Virus in Nonhuman Primate Models.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Gross and Histopathologic Evaluation of Tissues from Marburg Virus-Infected Nonhuman Primates.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Pathogenicity and virulence of African swine fever virus.Virulence · 2024Review
- Marmosets as models of infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug.Drug design, development and therapy · 2021Article
- Marmosets: Welfare, Ethical Use, and IACUC/Regulatory Considerations.ILAR journal · 2020Review
- Comparative Pathology and Pathogenesis of African Swine Fever Infection in Swine.Frontiers in veterinary science · 2020Review
- Marburg virus pathogenesis - differences and similarities in humans and animal models.Virology journal · 2019Review
- Recent advances in marburgvirus research.F1000Research · 2019Review
- A hamster model for Marburg virus infection accurately recapitulates Marburg hemorrhagic fever.Scientific reports · 2016Article
- Neglected filoviruses.FEMS microbiology reviews · 2016Review
- Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus).International journal of experimental pathology · 2014Article
- Advances in marmoset and mouse models buoy Ebola research.Nature medicine · 2014Article
- Review
- Exploring the innate immunological response of an alternative nonhuman primate model of infectious disease; the common marmoset.Journal of immunology research · 2014Article
- Article
- A novel nonhuman primate model for influenza transmission.PloS one · 2013Article
- A review of filovirus work and facilities at the Defence Science and Technology Laboratory Porton Down.Viruses · 2012Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marburg virus causes a highly infectious and lethal haemorrhagic fever in primates and may be exploited as a potential biothreat pathogen. To combat the infection and threat of Marburg haemorrhagic fever, there is a need to develop and license appropriate medical countermeasures. To determine whether the common marmoset (Callithrix jacchus) would be an appropriate model to assess therapies against Marburg haemorrhagic fever, initial susceptibility, lethality and pathogenesis studies were performed. Low doses of virus, between 4 and 28 TCID50 , were sufficient to cause a lethal, reproducible infection. Animals became febrile between days 5 and 6, maintaining a high fever before succumbing to disease between 8 and 11 days postchallenge. Typical signs of Marburg virus infection were observed including haemorrhaging and a transient rash. In pathogenesis studies, virus was isolated from the animals' lungs from day 3 postchallenge and from the liver, spleen and blood from day 5 postchallenge. Early signs of histopathology were apparent in the kidney and liver from day 3. The most striking features were observed in animals exhibiting severe clinical signs, which included high viral titres in all organs, with the highest levels in the blood, increased levels in liver function enzymes and blood clotting times, decreased levels in platelets, multifocal moderate-to-severe hepatitis and perivascular oedema.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.