ArticleThe Journal of clinical and aesthetic dermatology2013
Acne Vulgaris and the Epidermal Barrier: Is Acne Vulgaris Associated with Inherent Epidermal Abnormalities that Cause Impairment of Barrier Functions? Do Any Topical Acne Therapies Alter the Structural and/or Functional Integrity of the Epidermal Barrier?
Article in The Journal of clinical and aesthetic dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Alterations in the lipid profile in acne vulgaris patients: A meta-analysis.The Journal of international medical research · 2026Pooled it
- Clinical Measurement of Transepidermal Water Loss.Advances in wound care · 2026Review
- The Role of Dermocosmetics in Acne Management: Asian Perspective.Clinical, cosmetic and investigational dermatology · 2026Article
- From Monotherapy to Adjunctive Therapies: Application of Dermocosmetics in Acne Management Across Australia and New Zealand.The Australasian journal of dermatology · 2025Review
- One Acne™: A holistic management approach to improve overall skin quality and treatment outcomes in acne with or without sensitive skin.International journal of dermatology · 2025Review
- Lipid Dysregulation in Sebaceous Gland Disorders and the Impact of Sphingolipid Metabolism on Acne Pathogenesis.Cureus · 2025Review
- Skin 101: Understanding the Fundamentals of Skin Barrier Physiology-Why is This Important for Clinicians?The Journal of clinical and aesthetic dermatology · 2025Review
- An In Vitro Study of the Anti-Acne Effects ofMolecules (Basel, Switzerland) · 2025Article
- Development and Evaluation of Trans-Resveratrol-Loaded Transfersomes: Role of Cholesterol in Formulation Design for Dermal Delivery.Nanotechnology, science and applications · 2025Article
- Individual sol-gel microencapsulation of benzoyl peroxide and tretinoin enables controlled release onto the skin.Heliyon · 2024Article
- Allergenicity and marketing characteristics of 100 popular over-the-counter acne treatments.Archives of dermatological research · 2024Article
- Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies.International journal of molecular sciences · 2024Review
- Gel-Dispersed Nanostructured Lipid Carriers Loading Thymol Designed for Dermal Pathologies.International journal of nanomedicine · 2024Article
- Skin Barrier Parameters in Acne Vulgaris versus Normal Controls: A Cross-Sectional Analytic Study.Clinical, cosmetic and investigational dermatology · 2024Article
- Influence of Season on Efficacy and Tolerability of Tazarotene 0.045% Lotion for the Treatment of Acne.The Journal of clinical and aesthetic dermatology · 2023Article
- TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes.Communications biology · 2023Article
- Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study.Clinical, cosmetic and investigational dermatology · 2023Article
- Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial.Contemporary clinical trials communications · 2021Article
- Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits.Dermatology and therapy · 2021Review
- Literature mapping: association of microscopic skin microflora and biomarkers with macroscopic skin health.Clinical and experimental dermatology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acne vulgaris is a common dermatological disorder that predominantly affects teenagers, but can also affect preadolescents and post-teen individuals. Despite the fact that acne vulgaris is the most common skin disorder encountered in ambulatory dermatology practice in the United States, there has been limited research on the epidermal permeability barrier in untreated skin of people with acne vulgaris and also after use of acne therapies. This article reviews the research results and discusses the available literature on this subject area. The importance of proper skin care as a component of the management of acne vulgaris is supported by the information that is currently available.
Identifiers
23441236PMC3579484W2994126163What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.