ArticleHSR proceedings in intensive care & cardiovascular anesthesia2010
Cytokines in the systemic inflammatory response syndrome: a review.
Article in HSR proceedings in intensive care & cardiovascular anesthesia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Comparing the Predictive Value of SOFA and SIRS for Mortality in the Early Hours of Hospitalization of Sepsis Patients: A Systematic Review and Meta-analysis.Archives of Iranian medicine · 2024Pooled it
- Immune responses to topical emollient therapy with sunflower seed oil in young children with severe acute malnutrition in Bangladesh: a randomized controlled trial.Pediatric research · 2026Trial
- Impact of minimal invasive extracorporeal circulation on systemic inflammatory response - a randomized trial.Journal of cardiothoracic surgery · 2024Trial
- Sleep quality following hematopoietic stem cell transplantation: longitudinal trajectories and biobehavioral correlates.Bone marrow transplantation · 2014Trial
- Comorbidities and Inflammation: How Chronic Diseases Prime the Host Response in Sepsis.International journal of molecular sciences · 2026Review
- Renal Ischemia-Reperfusion and Uremic Toxins Modulate the Aortic Adenosinergic Axis in Acute Kidney Injury.International journal of molecular sciences · 2026Article
- Extracorporeal Cytokine Hemadsorption with oXirisJournal of clinical medicine · 2026Article
- Pro-inflammatory cytokine-driven molecular signaling in skeletal muscle during cancer cachexia.Biochemical Society transactions · 2026Review
- Recombinant Human SLPI Surface Functionalization Enhances Early Osseointegration and Biomechanical Stability of Titanium Implants in Rat Model.Journal of functional biomaterials · 2026Article
- Dynamic perioperative inflammatory biomarkers predict intrauterine adhesion formation following hysteroscopic myomectomy: a prospective cohort study.Frontiers in medicine · 2026Article
- Endothelial glycocalyx thickness in cats with naturally occurring trauma or non-traumatic illness: an exploratory study.Frontiers in veterinary science · 2026Article
- PostbioticFrontiers in immunology · 2026Article
- Dynamic and functional changes in vascular endothelial cell monolayers under combined hypoxic and inflammatory stimuli.Scientific reports · 2025Article
- Leveraging microbiota-metabolites to reduce inflammation and promote functional recovery following spinal cord injury in female mice.Brain, behavior, & immunity - health · 2025Article
- Significant Associations Between Blood Cell Counts and Plasma Cytokines, Chemokines, and Growth Factors.International journal of molecular sciences · 2025Article
- A Systematic Review of Case Reports of New-Onset Atrial Fibrillation in COVID-19 Patients.Cureus · 2025Review
- Novel insights into the ROCK-JAK-STAT signaling pathway in upper respiratory tract infections and neurodegenerative diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Recent Advances in the Mechanisms of Postoperative Neurocognitive Dysfunction: A Narrative Review.Biomedicines · 2025Review
- Nanoparticle approaches for manipulating cytokine delivery and neutralization.Frontiers in immunology · 2025Review
- Transcriptomic evidence of cytokine storm and sepsis in little brown bats exposed to white-nose syndrome.Conservation physiology · 2025Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients subject to major surgery, suffering sepsis, major trauma, or following cardiopulmonary bypass exhibit a systemic inflammatory response. This inflammatory response involves a complex array of inflammatory polypeptide molecules known as cytokines. It is well accepted that the loss of local control of the release of these cytokines leads to systemic inflammation and potentially deleterious consequences including the Systemic Inflammatory Response Syndrome, Multi-Organ Dysfunction Syndrome, shock and death.
methodsThe Medline database was searched for literature on mechanisms involved in the development of SIRS and potential targets for modifying the inflammatory response. We focus on the novel therapy of cytokine adsorption as a promising removal technology.
resultsAccumulating data from human studies and experimental animal models suggests that both pro- and anti- inflammatory cytokines are released following a variety of initiating stimuli including endotoxin release, complement activation, ischaemia reperfusion injury and others. DISCUSSION: Pro-and anti-inflammatory cytokines interact in a complex and unpredictable manner to influence the immune system and eventually cause multiple end organ effects. Cytokine adsorption therapy provides a potential solution to improving outcomes following Systemic Inflammatory Response Syndrome.
Indexed as
Identifiers
23441054PMC3484588W2151259793What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.